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Homo sapiens

ABSTRACT: Dynamics of the human skeletal muscle transcriptome in response to exercise training - part 1

OTHER RELATED OMICS DATASETS IN: E-GEOD-60590

PROVIDER: PRJNA258599 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1555180_1.fastq.gz	Fastqsanger.gz
	SRR1555180_2.fastq.gz	Fastqsanger.gz
	SRR1555190_1.fastq.gz	Fastqsanger.gz
	SRR1555190_2.fastq.gz	Fastqsanger.gz
	SRR1555200_1.fastq.gz	Fastqsanger.gz

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Project description:A single bout of exercise induces changes in gene expression in skeletal muscle. Regular exercise results in an adaptive response involving changes in muscle architecture and biochemistry, and is an effective way to manage and prevent common human diseases such as obesity, cardiovascular disorders and type II diabetes. Our study is a transcriptome-wide analysis of skeletal muscle tissue in a large cohort of untrained Thoroughbred horses before and after a bout of high-intensity exercise and again after an extended period of training. We hypothesized that regular high-intensity exercise training primes the transcriptome for the demands of high-intensity exercise.

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Dynamics of the human skeletal muscle transcriptome in response to exercise training - part 2

Project description:In the present study 23 participants completed three months of supervised aerobic exercise training of one leg (training period 1) followed by 9 months of rest before 12 of the participants completed a second exercise training period (training period 2) of three months of both legs. Skeletal muscle biopsies have been collected before and after the training periods. We have compared trained leg with untrained leg and studied gene and isoform expression. Additional samples included in this study has been previously submitted (GEO accession number GSE58387 and GSE60590). Analyze of transcriptome in skeletal muscle biopsy samples in response to exercise training in 23 participants in total (in addition to data previously submitted GEO accession number GSE58387 and GSE60590). Biopsy is collected from skeletal muscle before and after training period.

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