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Homo sapiens

ABSTRACT: H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia

PROVIDER: PRJNA262005 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1585480_1.fastq.gz	Fastqsanger.gz
	SRR1585480_2.fastq.gz	Fastqsanger.gz
	SRR1585481_1.fastq.gz	Fastqsanger.gz
	SRR1585481_2.fastq.gz	Fastqsanger.gz
	SRR1585482_1.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:H3K4me3 and H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia and reoxygenation

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Homo sapiens

Project description:Gene expression profiling in MCF7 cell lines under hypoxia and reoxygenation

| PRJNA289570 | ENA

H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia

Project description:Purpose: Study hypoxia induced changes in genome-wide H3K27me3 occupancy Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we combined chromatin-immunoprecipitation and deep-sequencing analysis to identify H3K27me3-marks in MCF7 cells subjected to changes in oxygenation (i.e. acute hypoxia, chronic hypoxia). Results: H3K27me3-marks showed a rapid global increase at specific sites throughout the genome under hypoxia, both genic and inter-genic. Conclusions: Our data show that oxygen availability dynamically regulates the epigenetic state of the genome. Genome-wide H3K27me3-mark profiles were generated by combining ChIP analysis with deep sequencing using Illumina GAIIx.

2014-09-26 | E-GEOD-61740 | biostudies-arrayexpress

H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia

2014-09-26 | GSE61740 | GEO

H3K4me3 and H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia and reoxygenation

Project description:Purpose: Study hypoxia and reoxygenation induced changes in genome-wide H3K4me3 and H3K27me3 occupancy Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we combined chromatin-immunoprecipitation and deep-sequencing analysis to identify H3K4me3-marks and H3K27me3-marks in MCF7 cells subjected to changes in oxygenation (i.e. acute hypoxia, chronic hypoxia, reoxygenation). Results: H3K4me3 and H3K27me3-marks showed a rapid global increase at specific sites throughout the genome under hypoxia, both genic and inter-genic, that was partly restored upon reoxygenation. Conclusions: Our data show that oxygen availability dynamically regulates the epigenetic state of the genome.

2016-11-01 | GSE71030 | GEO

High resolution analysis of epigenetic changes associated with X inactivation, ChIP-Seq

Project description:This study describes the epigenetic profiling of the X chromosome during X inactivation. It includes H3K4me3 and H3K27me3 ChIP-Seq profiles of male (E14) and female (LF2 and XT67E1) mouse ES cells, together with their differentiated derivatives (either 4d atRA or 10d EB). It also includes ChIP-chip profiles around the Xic on chromosome X of H3K4me3, H3K27me3, H3K9me2, H3K36me3, Pol II, TBP, H3-Core as well as expression, using male (E14) and female (LF2) mouse ES cells, together with their differentiated derivatives (either 4d atRA or 10d EB). Examination of two different histone modifications in 3 cell lines under 3 conditions using ChIP-Seq. Examination of five different histone modifications two transcription factors and gene expression under three conditions in 2 cell lines using ChIP-chip.

2009-06-06 | E-GEOD-15814 | biostudies-arrayexpress