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KAT6B gene deletion as a predictive biomarker to Irinotecan response in small cell lung cancer

ABSTRACT: KAT6B gene deletion as a predictive biomarker to Irinotecan response in small cell lung cancer

PROVIDER: PRJNA265094 | ENA |

REPOSITORIES: ENA

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KAT6B gene deletion in small cell lung cancer

Project description:Copy number analysis of KAT6B gene deletion in small cell lung cancer cell lines

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KAT6B gene deletion as a predictive biomarker to Irinotecan response in small cell lung cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-10-07 | GSE62775 | GEO

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The histone acetyltransferase KAT6B is required for haematopoietic stem cell development and function

Project description:The histone lysine acetyltransferase KAT6B (MYST4, MORF, QKF) is the target of recurrent chromosomal translocations causing haematological malignancies with poor prognosis. Using Kat6b germline deletion and overexpression in mice, we determined the role of KAT6B in the haematopoietic system. We found that KAT6B sustained the fetal haematopoietic stem cell pool but did not affect viability or differentiation. KAT6B was essential for normal levels of histone H3 lysine 9 (H3K9) acetylation but not for a previously proposed target, H3K23. Compound heterozygosity of Kat6b and the closely related gene, Kat6a, abolished haematopoietic reconstitution after transplantation. KAT6B and KAT6A cooperatively promoted transcription of genes regulating haematopoiesis, including the Hoxa cluster, Pbx1, Meis1, Gata family, Erg and Flt3. In conclusion, we identified the haematopoietic processes requiring Kat6b and showed that KAT6B and KAT6A synergistically promoted HSC development, function and transcription. Our findings are pertinent to current clinical trials testing KAT6A/B inhibitors as cancer therapeutics.

2024-02-25 | GSE256039 | GEO

Identification of KAT6B signature on KAT6B deficient SCLC cell Lines

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CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in osteosarcoma patients

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CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

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RNA sequencing of cortical neurons from Kat6b deficient mouse foetuses

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