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Drosophila melanogaster

ABSTRACT: Drosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation

PROVIDER: PRJNA266435 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1640740.fastq.gz	Fastqsanger.gz
	SRR1640741.fastq.gz	Fastqsanger.gz
	SRR1640742.fastq.gz	Fastqsanger.gz
	SRR1640733.fastq.gz	Fastqsanger.gz
	SRR1640743.fastq.gz	Fastqsanger.gz

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Drosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation

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Drosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation

Project description:In this study, we employed a combination of RIP-seq and short- and long-wave iCLIP technologies to identify transcripts associated with cytoplasmic RNPs containing the RNA-binding protein Drosophila Imp. We also made a Imp knockdown vs luciferase control experiment. Two biological iCLIP-seq, as well as two mRNAseq made on cells harvested on the same day. Two biological PAR-iCLIP-seq. Two biological RIP-seq, as well as two mRNAseq made on cells harvested on the same day. Three biological mRNAseq of imp dsRNA treated cells as well as three control mRNAseq of cells treated with Luciferase dsRNA.

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Project description:Pediatric neural tumors are initiated during embryonic/fetal stages and rapidly become malignant despite carrying few genetic alterations. However, the molecular basis of this early malignant susceptibility remains unknown. During Drosophila development, malignant neural tumors can arise from single gene inactivation triggering dedifferentiation towards a neural stem cell (NSC)-like state. Here, we find that these tumors originate from a sub-population of early-born neural progeny that transiently co-express the mRNA-binding proteins Lin-28 and Imp/IGF2BP, and the transcription factor Chinmo. These three genes compose an early growth module that is co-opted in a subset of dedifferentiated cells to propagate unlimited proliferation. In late NSCs, Chinmo, Imp and Lin-28 are silenced by temporal transcription factors for timely termination of neurogenesis. Consequently, late-born progeny do not express the module and become refractory to malignant transformation. Thus, this study identifies the NSC-intrinsic developmental program that predisposes neural progeny to malignant transformation according to their birth order.

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