Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Role of de novo DNA methyltransferases in hematopoietic stem cells (ChIP-Seq)

PROVIDER: PRJNA267127 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1652040_1.fastq.gz	Fastqsanger.gz
	SRR1652040_2.fastq.gz	Fastqsanger.gz
	SRR1652041_1.fastq.gz	Fastqsanger.gz
	SRR1652041_2.fastq.gz	Fastqsanger.gz
	SRR1652042_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Mus musculus

Project description:Role of de novo DNA methyltransferases in hematopoietic stem cells (WGBS)

| PRJNA218940 | ENA

Mus musculus

Project description:Role of de novo DNA methyltransferases in hematopoietic stem cells (RNA-seq)

| PRJNA218934 | ENA

Project description:Role of de novo DNA methyltransferases in hematopoietic stem cells

| PRJNA218939 | ENA

Mus musculus

Project description:de novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation

| PRJNA137177 | ENA

Mus musculus

Project description:De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [BS-Seq]

| PRJNA289448 | ENA

Mus musculus

Project description:De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [RNA-Seq]

| PRJNA289454 | ENA

Mus musculus

Project description:De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [TAB-Seq]

| PRJNA289453 | ENA

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)

2016-01-11 | GSE71039 | GEO

Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)

Project description:The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells, and Dnmt3b has recently been shown to play a role in genic methylation. Forced Dnmt3b expression induced widespread DNA hypermethylation in myc-bcl2 induced leukemias, especially at promoters and gene bodies of stem cell-related genes. MLL-AF9 induced leukemogenesis showed much less pronounced DNA hypermethylation upon Dnmt3b expression. Nonetheless, leukemogenesis was delayed in both models with a shared core set of DNA hypermethylated regions and suppression of stem cell-related genes. Our findings indicate a critical role for Dnmt3b-mediated DNA methylation in leukemia development and maintenance of LSC function. To investigate how Dnmt3b-mediated DNA methylation affects leukemogenesis, we analyzed leukemia development under conditions of high and physiological methylation levels in a tetracycline-inducible knockin mouse model. High expression of Dnmt3b slowed leukemia development in serial transplantations and impaired leukemia stem cell (LSC) function.

2016-01-11 | E-GEOD-71039 | biostudies-arrayexpress

Mus musculus hematopoietic stem cell

Project description:A transcriptome study in mouse hematopoietic stem cells was performed using a sensitive SAGE method, in an attempt to detect medium and low abundant transcripts expressed in these cells. Among a total of 31,380 unique transcript, 17,326 (55%) known genes were detected, 14,054 (45%) low-copy transcripts that have no matches to currently known genes. 3,899 (23%) were alternatively spliced transcripts of the known genes and 3,754 (22%) represent anti-sense transcripts from known genes.

2009-05-20 | GSE16139 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data