Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [RRBS]

OTHER RELATED OMICS DATASETS IN: GSE69351GSE62777

PROVIDER: PRJNA267700 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1656650.fastq.gz	Fastqsanger.gz
	SRR1656660.fastq.gz	Fastqsanger.gz
	SRR1656651.fastq.gz	Fastqsanger.gz
	SRR1656661.fastq.gz	Fastqsanger.gz
	SRR1656652.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 17

Similar Datasets

Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency

| PRJNA265093 | ENA

Homo sapiens

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [shRNA]

| PRJNA290154 | ENA

Homo sapiens

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [smartseq2]

| PRJNA285094 | ENA

Homo sapiens

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [ChIP-Seq]

| PRJNA290153 | ENA

Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [SCRB-Seq]

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [SCRB-Seq]

| PRJNA285283 | ENA

Homo sapiens

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [mRNA-Seq]

| PRJNA265099 | ENA

Homo sapiens

Project description:Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency [small RNA-Seq]

| PRJNA265101 | ENA

Defining a molecular roadmap of cellular reprogramming into iPS Cells [DNA methylation]

Project description:Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcriptional waves, which are driven by c-Myc/Klf4 (first wave) and Oct4/Sox2/Klf4 (second wave). Cells that become refractory to reprogramming activate the first but fail to initiate the second transcriptional wave and can be rescued by elevated expression of all four factors. The establishment of bivalent domains occurs gradually after the first wave, whereas changes in DNA methylation take place after the second wave when cells acquire stable pluripotency. This integrative analysis allowed us to identify genes that act as roadblocks during reprogramming and surface markers that further enrich for cells prone to forming iPSCs. Collectively, our data offer new mechanistic insights into the nature and sequence of molecular events inherent to cellular reprogramming. DNA methylation profiles obtained at different timepoints during reprogramming of somatic cells: Day 0, +3, +6, +9 and iPSC

2013-03-18 | E-GEOD-45248 | biostudies-arrayexpress

Homo sapiens

Project description:Integrative analysis of reprogramming human fibroblast cells to naïve pluripotency [RRBS]

| PRJNA350172 | ENA