Macaca mulatta
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA270891 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Molecular and Structural Bases of Hypothalamic Development
| PRJNA270781 | ENA
Project description:Female Rhesus Monkey hypothalamic gene expression profiling during puberty
| PRJNA101585 | ENA
Project description:Conserved and species specific molecular denominators in mammalian aging [rhesus monkey]
| PRJNA343554 | ENA
Project description:Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration
| PRJNA289573 | ENA
Project description:Mass spectrometry based proteomics has facilitated sperm composition studies in several mammalian species but no studies have been undertaken in non-human primate species. Here we report the analysis of the 1247 proteins that comprise the Rhesus macaque (Macaca mulatta) sperm proteome (termed the MacSP). Comparative analysis with previously characterized mouse and human sperm proteomes reveals substantial levels of orthology (47% and 40% respectively) and widespread overlap of functional categories based on Gene Ontology analyses. Approximately 10% of macaque sperm genes (113/1247) are significantly under-expressed in the testis as compared with other tissues, which may reflect proteins specifically acquired during epididymal maturation. Phylogenetic and genomic analyses of three MacSP ADAMs (A-Disintegrin and Metalloprotease proteins), ADAM18-, 20- and 21-like, provides empirical support for sperm genes functioning in non-human primate taxa which have been subsequently lost in the lineages leading to humans. The MacSP contains proteasome proteins of the 20S core subunit, the 19S proteasome activator complex and an alternate proteasome activator PA200, raising the possibility that proteasome activity is present in mature sperm. Robust empirical characterization of the Rhesus sperm proteome should greatly expand the possibility for targeted molecular studies of spermatogenesis and fertilization in a commonly used model species for human infertility.
| S-EPMC3820923 | biostudies-literature
Project description:Macaca mulatta whole genome shotgun sequencing project by the Institute of Molecular Biotechnology, Genome Analysis, Germany, Jena
| PRJNA18243 | ENA
Project description:Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction
| PRJNA151521 | ENA
Project description:Rhythms of life on earth are shaped by the seasons. Accordingly, various physiological functions such as hormonal secretion, metabolism, growth, immune function, and reproduction show profound seasonal changes in animals including humans. Morbidity in humans due to cardiovascular disease, influenza, and psychiatric diseases is also seasonally regulated and peaks in winter. However, their underlying molecular bases remain unknown. Non-human primates (NHPs) represent the nearest-to-human alternative and are crucial to understand human physiology and diseases. In this study, we identifed genes that showed seasonal oscillations in the expressions for each of the 80 tissues, including 30 brain regions and 50 peripheral tissues collected every 2 months from male and female NHP rhesus macaques (Macaca mulatta) that were kept under seminatural outdoor conditions. In addition, the seasonal transcriptome partterns can be checked in our web database entitled “Non-Human Primate Seasonal Transcriptome Atlas (NHPSTA)”. The overall study contributes to our understanding of the molecular basis for seasonally regulated physiological mechanisms and provides potential biomarkers and targets for developing novel therapeutic intervention for seasonally regulated diseases.
2025-02-01 | GSE201986 | GEO
Project description:Puberty marks the end of childhood and achieve sexual maturation and fertility. The role of hypothalamic proteins in regulating puberty onset is unclear. We performed a comprehensive differential proteomics and phosphoproteomics analysis in prepubertal and pubertal goats to determine the roles of hypothalamic proteins and phosphoproteins during the onset of puberty.
2023-04-06 | PXD041426 |
Project description:Plasmodium knowlesi, a model malaria parasite, is responsible for a significant portion of zoonotic malaria cases in Southeast Asia and must be controlled to avoid disease severity and fatalities. However, little is known about the host-parasite interactions and molecular mechanisms in play during the course of P. knowlesi malaria infections, which also may be relevant across Plasmodium species. Here we contrast P. knowlesi sporozoite-initiated infections in Macaca mulatta and Macaca fascicularis using whole blood RNA-sequencing and transcriptomic analysis. These macaque hosts are evolutionarily close, yet malaria-naïve M. mulatta will succumb to blood-stage infection without treatment, whereas malaria-naïve M. fascicularis controls parasitemia without treatment. This comparative analysis reveals transcriptomic differences as early as the liver phase of infection, in the form of signaling pathways that are activated in M. fascicularis, but not M. mulatta. Additionally, while most immune responses are initially similar during the acute stage of the blood infection, significant differences arise subsequently. The observed differences point to prolonged inflammation and anti-inflammatory effects of IL10 in M. mulatta, while M. fascicularis undergoes a transcriptional makeover towards cell proliferation, consistent with its recovery. Together, these findings suggest that timely detection of P. knowlesi in M. fascicularis, coupled with control of inflammation while initiating the replenishment of key cell populations, helps contain the infection. Overall, this study points to specific genes and pathways that could be investigated as a basis for new drug targets that support recovery from acute malaria.
| S-EPMC8484567 | biostudies-literature