Papio hamadryas
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA273306 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation [miRNA-seq]
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Project description:Primate fetal hepatic response to maternal obesity: epigenetic signaling pathways and lipid accumulation [gene expression]
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Project description:Expression of the placental transcriptome in fetal growth restriction in the Baboon is Dependent on Fetal Sex
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Project description:Investigation of spatial transcriptomic responses of nonhuman primate fetal brains during development
2023-11-02 | GSE227533 | GEO
Project description:Identification of primate renal salt-responsive gene networks that differ by blood pressure phenotype
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Project description:Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Undernutrition
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Project description:Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
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Project description:Little is known about the repertoire of nonhuman primate kidney genes expressed throughout development. The present work establishes an understanding of the primate renal transcriptome at different stages of fetal development and defines the framework of gene expression in the context of renal maturation, which provides a basis for identifying deviations in transcriptome expression resulting from suboptimal conditions during renal development. The baboon kidney transcriptome was characterized at 60 days gestation (DG), 90DG, 125DG, 160DG and adulthood (6-12 years) using human genome arrays to identify differential gene expression in the context of biological pathways and hierarchical clusters. Whole genome expression profiling showed 11,331 genes that were expressed during kidney development, 4,698 of which were differentially expressed among the developmental time points. Pathway analysis indicated activation of annotated pathways previously reported to be important to kidney development and pathways not reported as relevant to kidney development. QRT-PCR for genes central to these pathways validated expression profiles and revealed differences between males and females at specific times in gestation. Hierarchical clustering indicated that two clusters best fit the data, one containing genes that increased in expression from 60DG to adult and one that decreased. Cluster analysis also revealed gene splice variants with discordant expression profiles during development. For example, SMAD4, which is central to Wnt signaling, TGF-β signaling and cell cycle, showed up-regulation of the full-length splice variant during development and down-regulation of a shorter variant that is missing DNA binding and protein heterotrimerization domains suggesting decreased inhibition of cell proliferation, which may impact renal cell number and maturation. This study provides the first detailed genetic analysis of the developing primate kidney, and our findings of discordant expression of gene splice variants suggest that gene arrays likely provide a simplified view and demonstrate the need to study the fetal renal proteome.
2018-01-20 | GSE65162 | GEO
Project description:Effects of Intrauterine Growth Restriction on Ribosomal Subunit mRNA and Protein Expression in the Frontal Cortex of Near-Term Fetal Baboons
| PRJNA183060 | ENA
Project description:Papio hamadryas (taxid:9557) Transcriptome or Gene expression
| PRJNA167997 | ENA