Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Genome-wide maps of Brd7 binding sites in control and BRD7 overexpressed cells.

PROVIDER: PRJNA275630 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1805900.fastq.gz	Fastqsanger.gz
	SRR1805899.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Genome-wide maps of Brd7 binding sites in control and BRD7 overexpressed cells.

Project description:We applied Chromatin immunoprecipation and massively parallel DNA sequencing technique, ChIP-seqencing, to identify the binding sites of Brd7 protein in human cells. ChIP-seq was applied to HEK293 cell line in control and BRD7 overexpressed cells.

2018-02-12 | GSE65974 | GEO

Homo sapiens

Project description:Genome-wide maps of ERbeta binding sites in U2OS cells

| PRJNA129355 | ENA

Homo sapiens

Project description:Genome-wide maps of SOX2 binding sites in lung cancer cells

| PRJNA382356 | ENA

Homo sapiens

Project description:Genome-wide maps of polyadenylation sites in control and PABPN1kd cells

| PRJNA153917 | ENA

Homo sapiens

Project description:Genome-wide maps of SOX9 binding sites in human colorectal cancer cells

| PRJNA268497 | ENA

Homo sapiens

Project description:Genome-wide maps of MBD3 binding sites in HEK393T cell

| PRJNA399514 | ENA

BRD7 is a candidate tumour suppressor gene required for p53 function

Project description:Oncogene-induced senescence (OIS) is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations while others show a dysfunctional p53 pathway, frequently by unknown mechanisms. We identified BRD7, a bromodomain-containing protein whose inhibition allows full neoplastic transformation in the presence of wild-type p53. Intriguingly, in human breast tumours harbouring wild-type, but not mutant p53, the BRD7 gene locus was frequently deleted and low BRD7 expression was found in a subgroup of tumours. Functionally, BRD7 is required for efficient p53-mediated transcription of a subset of target genes. BRD7 interacts with p53 and p300, and is recruited to target gene promoters, affecting histone acetylation, p53 acetylation, and promoter activity. Thus, BRD7 suppresses tumourigenicity by serving as a p53 cofactor required for efficient induction of p53-dependent OIS. We recorded mRNA expression profiles of BJ primary fibroblasts expressing the oncogene RasV12 and either control vector, one of two BRD7 knockdown vectors, or p53 knockdown vector. In addition, we profiled genome-wide protein DNA interactions for p53 and BRD7 using ChIP-Seq. p53- and BRD7-binding sites were recorded in RasV12-expressing BJ cells; as a control we used knockdown of the gene of interest (BRD7 or p53).

2010-03-14 | E-GEOD-20076 | biostudies-arrayexpress

Homo sapiens

Project description:Genome wide maps of p53 binding in IMR90 cells

| PRJNA182950 | ENA

Homo sapiens

Project description:Genome wide maps of E2F7 binding in IMR90 cells

| PRJNA173795 | ENA

Homo sapiens

Project description:Genome-wide maps of TRIM25 binding sites in triple negative breast cancer cell

| PRJNA316330 | ENA