Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Gene expression profile of hepatic lincRNAs in female mouse liver using nuclear RNA-Seq

PROVIDER: PRJNA275766 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1810240_1.fastq.gz	Fastqsanger.gz
	SRR1810240_2.fastq.gz	Fastqsanger.gz
	SRR1810241_1.fastq.gz	Fastqsanger.gz
	SRR1810241_2.fastq.gz	Fastqsanger.gz
	SRR1810236_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mus musculus

Project description:Gene expression profile of hepatic lincRNAs in male mouse liver using nuclear RNA-Seq

| PRJNA275764 | ENA

Gene expression profile of hepatic lincRNAs in female mouse liver using nuclear RNA-Seq

Project description:Gene expression in adult female mouse liver was assayed by nuclear RNA-seq, as part of a study of hepatic lincRNAs.

2015-10-21 | GSE66007 | GEO

Identification of sex-specific hepatic lincRNAs using nuclear RNA-Seq

Project description:Gene expression in adult male and female mouse liver was analyzed based on nuclear RNA-seq, as part of a study on hepatic lincRNAs.

2015-10-21 | GSE66000 | GEO

Mus musculus

Project description:Identification of sex-specific hepatic lincRNAs using nuclear RNA-Seq

| PRJNA275763 | ENA

Sex-specific early growth hormone responses in mouse liver (Mus musculus)

Project description:Sex differences in liver gene expression are dictated by sex-differences in circulating growth hormone (GH) profiles. Presently, the pituitary hormone dependence of mouse liver gene expression was investigated on a global scale to discover sex-specific early GH response genes that might contribute to sex-specific regulation of downstream GH targets and to ascertain whether intrinsic sex-differences characterize hepatic responses to plasma GH stimulation. RNA expression analysis using 41,000-feature microarrays revealed two distinct classes of sex-specific mouse liver genes: genes subject to positive regulation (class-I) and genes subject to negative regulation by pituitary hormones (class-II). Genes activated or repressed in hypophysectomized (Hypox) mouse liver within 30-90min of GH pulse treatment at a physiological dose were identified as direct targets of GH action (early response genes). Intrinsic sex-differences in the GH responsiveness of a subset of these early response genes were observed. Notably, 45 male-specific genes, including five encoding transcriptional regulators that may mediate downstream sex-specific transcriptional responses, were rapidly induced by GH (within 30min) in Hypox male but not Hypox female mouse liver. The early GH response genes were enriched in 29 male-specific targets of the transcription factor Mef2, whose activation in hepatic stellate cells is associated with liver fibrosis leading to hepatocellular carcinoma, a male-predominant disease. Thus, the rapid activation by GH pulses of certain sex-specific genes is modulated by intrinsic sex-specific factors, which may be associated with prior hormone exposure (epigenetic mechanisms) or genetic factors that are pituitary-independent, and could contribute to sex-differences in predisposition to liver cancer or other hepatic pathophysiologies.

2010-01-27 | GSE17644 | GEO

Expression and transcriptional regulation dynamics of hepatic lincRNAs

Project description:Gene expression in adult male and female mouse liver was assayed by RNA-seq, as part of a study on hepatic lincRNAs.

2015-10-21 | GSE65444 | GEO

Impact of Cux2 knockdown on gene expression in female mouse liver (Mus musculus)

Project description:We identified genes expressed in mouse liver that are regulated by Cux2, a highly female-specific liver transcription factor whose expression is regulated by sex-dependent plasma GH patterns. Using siRNA to knockdown Cux2 expression in female liver, we show that female specific genes are predominantly repressed by Cux2 knockdown. In contrast, similar numbers of male-biased genes are repressed as are induced by Cux2 knockdown. A scrambled, non-specific siRNA was used as a control. (Published in: TL Conforto et al 2012, Mol Cell Biol. 2012, 32:4611-4627. PubMed PMID: 22966202; PMCID: PMC3486175)

2012-09-10 | GSE37078 | GEO

Gene expression profile of hepatic lincRNAs in male mouse liver using nuclear RNA-Seq

Project description:Gene expression in adult male mouse liver was assayed by nuclear RNA-seq, as part of a study of hepatic lincRNAs.

2015-10-21 | GSE66009 | GEO

Impact of Cux2 overexpression on gene expression in male and female mouse liver (Mus musculus)

Project description:We identified genes expressed in mouse liver that are regulated by Cux2, a highly female-specific liver transcription factor whose expression is regulated by sex-dependent plasma GH patterns. Using adenovirus to overexpress Cux2 (Adeno-Cux2) in male liver, we show that Cux2 represses ~35% of male-biased genes and induces/de-represses ~35% of female-biased genes. Adeno-CMV was used as a control for adenoviral infection. (Published in: TL Conforto et al 2012, Mol Cell Biol. 2012, 32:4611-4627. PubMed PMID: 22966202; PMCID: PMC3486175)

2012-09-10 | GSE35897 | GEO

Mus musculus

Project description:Gene expression profile of adult male mouse liver using total liver RNA-seq and nuclear liver RNA-Seq

| PRJNA275762 | ENA