Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Malignant Peritoneal Mesothelioma Exome Sequencing.

PROVIDER: PRJNA278669 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1917350.fastq.gz	Fastqsanger.gz
	SRR1917350_1.fastq.gz	Fastqsanger.gz
	SRR1917350_2.fastq.gz	Fastqsanger.gz
	SRR1917351.fastq.gz	Fastqsanger.gz
	SRR1917351_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 42

Similar Datasets

Homo sapiens

Project description:microRNA expression profiling in diffuse malignant peritoneal mesothelioma

| PRJNA388196 | ENA

Homo sapiens

Project description:Gene Expression Profiling of Malignant Peritoneal Mesothelioma Patient Tumor Samples

| PRJNA116599 | ENA

Homo sapiens

Project description:Malignant pleural mesothelioma

| PRJNA92153 | ENA

Molecular subtypes of malignant peritoneal mesothelioma

Project description:Malignant Peritoneal Mesothelioma (PeM) is a rare but frequently fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no targeted therapies for PeM yet exist. This study performs comprehensive integrative analysis of genome, transcriptome, and proteome of treatment-naïve PeM tumors with the aim of identifying mesothelioma-related molecular alterations and potentially identifying novel treatment strategies.

2018-12-11 | PXD008873 | Pride

Genomic profiles of asbestos-induced mesothelioma developed in wild-type and BRCA1+/- SD rats

Project description:Intraperitoneal administration of crocidolite or chrysotile is an established method to induce peritoneal malignant mesothelioma(MM), which shares common genetic alterations to those in humans. We conducted high-resolution microarray comparative genomic hybridization mesothelioma tissues obtained from both wild-type and BRCA1+/- rats to evaluate the involvement of BRCA1 haploinsufficiency in carcinogenesis.

2022-12-23 | GSE210598 | GEO

Genomic profiles of crocidolite-induced malignant peritoneal mesotheliomas developed in mice

Project description:Intraperitoneal injection of crocidolite initiates malignant peritoneal mesothelioma (MM) in mice. We performed high-resolution comparative genomic hybridization to identify characterstics in the genomic profiles of crocidolite-induced MM in the mice.

2020-03-22 | GSE139177 | GEO

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

Project description:Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed group I PAK member, affects the development of malignant mesothelioma in Nf2;Cdkn2a-deficient (NC) mice and the growth properties of NC mesothelioma cells in culture. In vivo, deletion of Pak2 resulted in a markedly decreased incidence and delayed onset of both pleural and peritoneal malignant mesotheliomas in NC mice. In vitro, Pak2 deletion decreased malignant mesothelioma cell viability, migration, clonogenicity, and spheroid formation. RNA-seq analysis demonstrated downregulated expression of Hedgehog and Wnt pathway genes in NC;Pak2-/- mesothelioma cells versus NC;Pak2+/+ mesothelioma cells. Targeting of the Hedgehog signaling component Gli1 or its target gene Myc inhibited cell viability and spheroid formation in NC;P+/+ mesothelioma cells. Kinome profiling uncovered kinase changes indicative of EMT in NC;Pak2-/- mesothelioma cells, suggesting that Pak2-deficient malignant mesotheliomas can adapt by reprogramming their kinome in the absence of Pak activity. The identification of such compensatory pathways offers opportunities for rational combination therapies to circumvent resistance to anti-PAK drugs.

2023-03-10 | PXD030571 | Pride

Homo sapiens

Project description:Whole exome and transcriptome sequencing of tumour cells from malignant mesothelioma pleural effusions

| PRJNA419580 | ENA

Gene Expression Profiling of Malignant Peritoneal Mesothelioma Patient Tumor Samples

Project description:Gene expression profiles were generated from 41 consecutive surgically resected fresh frozen malignant peritoneal mesothelioma patient tumor samples to identify molecular prognostic factors.

2010-09-27 | GSE15627 | GEO

Homo sapiens

Project description:Gene expression profile of malignant mesothelioma

| PRJNA140209 | ENA