Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Genome-wide changes in DNA methylation upon Dnmt3b loss in melanoma

PROVIDER: PRJNA279803 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1945050.fastq.gz	Fastqsanger.gz
	SRR1945047.fastq.gz	Fastqsanger.gz
	SRR1945048.fastq.gz	Fastqsanger.gz
	SRR1945049.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Genome-wide changes in DNA methylation upon Dnmt3b loss in melanoma

Project description:We report the genome wide DNA methylation changes in melanoma associated with inactivation of Dnmt3b.

2018-03-28 | GSE67392 | GEO

Mus musculus

Project description:Changes in DNA methylation upon gain and loss of Prdm16 function

| PRJNA255654 | ENA

Mus musculus

Project description:Changes in DNA methylation upon gain and loss of Prdm16 function (MeDIP-seq)

| PRJNA311225 | ENA

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt’s lymphoma

Project description:We performed methylation profiling using RRBS-seq to investigate the role of DNMT3B in MYC-driven tumor maintenance. Comparing tumor cells before and upon DNMT3B knock-down revealed genome-wide changes in the DNA methylation pattern.

2017-07-27 | GSE101907 | GEO

Methylation array of shNC, shUHRF1, shDNMT1, shDNMT3B THP-1 cells before and after PMA treatment

Project description:This methylation array was conducted to find out changes in genome-wide methylation pattern in THP-1 cells upon differentiation. Also, we tried to figure out the effects of knockdown of UHRF1, DNMT1 and DNMT3B in THP-1 cells in regulating genome-wide DNA methylation.

2022-06-24 | GSE206620 | GEO

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state

Project description:Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transduction of defined transcription factors and involves dynamic changes in DNA methylation. While the reprogramming of somatic cells is accompanied by de-methylation of pluripotency genes, the functional importance of de novo DNA methylation has not been clarified. Here, using loss-of-function studies, we generated iPSCs from fibroblasts that were deficient in de novo DNA methylation mediated by Dnmt3a and Dnmt3b. These iPSCs reactivated pluripotency genes, underwent self-renewal and showed restricted developmental potential which was rescued upon re-introduction of Dnmt3a and Dnmt3b. We conclude that de novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells. RNA levels of Dnmt3ab deficient iPSC cell lines were compared to control iPSC cell lines

2011-05-16 | E-GEOD-28629 | biostudies-arrayexpress

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state

2011-05-16 | GSE28629 | GEO

RNA-seq profiling of mouse PGC (Mus musculus)

Project description:PGCs undergo two distinct stages of demethylation before reaching a hypomethylated ground state at E13.5. Stage 1 occurs between E7.25- E9.5 in which PGCs experience a global loss of cytosine methylation. However, discreet loci escape this global loss of methylation and between E10.5-E13.5, stage 2 of demethylation takes place. In this stage these loci are targeted by Tet1 and Tet2 leading to the loss of the remaining methylation and resulting in the epigenetic ground state. Our data shows that Dnmt1 is responsible for maintaining the methylation of loci that escape stage 1 demethylation, and that it functions in a UHRF1 independent manner. Our data further demonstrates that when these loci lose methylation prior to stage 2 it results in early activation of the meiotic program, which leads to precocious differentiation of the germ line resulting in a decreased pool of PGCs in the embryo and subsequent infertility in adult mice.

2016-09-13 | GSE74938 | GEO

Mus musculus

Project description:Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (expression)

| PRJNA290165 | ENA

Mus musculus

Project description:Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (RRBS)

| PRJNA290166 | ENA