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Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme

ABSTRACT: Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme

PROVIDER: PRJNA280050 | ENA |

REPOSITORIES: ENA

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Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [II]

Project description:In order to elucidate the role of DNA methylation in the DME gene regulation, global DNA methylation and mRNA expression profiles of human tissues and cell lines were examinde by HumanMethylation450 Bead Chip and SurePrint G3 Human Gene Expression 8×60K v2. We demonstrated DNA methylation landscape of the DME genes in human tissues. Although a fraction of DME genes can be regulated by their DNA methylation, the variable DNA methylation status probably affects drug metabolism and response.

2015-06-16 | GSE67477 | GEO

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [I]

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Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [III]

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Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [II]

2015-06-16 | E-GEOD-67477 | biostudies-arrayexpress

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [III]

2015-06-16 | E-GEOD-67484 | biostudies-arrayexpress

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [I]

2015-06-16 | E-GEOD-67318 | biostudies-arrayexpress

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-16 | E-GEOD-67485 | biostudies-arrayexpress

Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-06-16 | GSE67485 | GEO

DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)

Project description:DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)

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Digital Restriction Enzyme Analysis of Methylation (DREAM) of SW48 colon cancer cell line genomic DNA.

Project description:We analyzed levels of 5-methyl cytosine nnnn CCCGGG target sites by sequential restriction digest by SmaI and XmaI enzymes, ligating Illumina adaptors to the restriction fragments and reading methylation-specific signatures at the ends of restriction fragments by paired ends Illumina high throughput sequencing. Digital restriction enzyme analysis of methylation (DREAM) was performed to determine the methylation profile of SW48 colon cancer cell line genomic DNA. Genomic DNA spiked in with unmethylated, partially methylated and fully methylated standards was sequentially cut at CCCGGG sites with the methylation-sensitive enzyme SmaI (blunt ends) and its methylation-tolerant neoschizomer XmaI (5'CCGG overhangs), creating different end sequences that represented methylation status of the CCCGGG sites. These end sequences were analyzed by Illumina high throughput sequencing. Methylation status at individual CCCGGG sites across the genome was determined by counting the methylated reads with the CCGGG signature and unmethylated reads with the GGG signature at the beginnings of the sequencing reads after alignment to the human genome.

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