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Trichomonas vaginalis

ABSTRACT: Trichomonas vaginalis Genome sequencing

PROVIDER: PRJNA280779 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2007500_1.fastq.gz	Fastqsanger.gz
	SRR2007500_2.fastq.gz	Fastqsanger.gz
	SRR2007510_1.fastq.gz	Fastqsanger.gz
	SRR2007510_2.fastq.gz	Fastqsanger.gz
	SRR2007520_1.fastq.gz	Fastqsanger.gz

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Transcription profiling of Trichomonas vaginalis cultured in the low-iron and high-iron conditions

Project description:Transcriptional changes of Trichomonas vaginalis cultured in the low-iron and high-iron conditions.

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Project description:Trichomonas vaginalis, a common sexually transmitted parasite that colonizes the human urogenital tract, secretes extracellular vesicles (TvEVs) that are taken up by human cells and are speculated to be taken up by parasites as well. While the crosstalk between TvEVs and human cells has led to insight into host:parasite interactions, the role of TvEVs in infection have largely been one-sided, with little known about the effect of TvEV uptake by T. vaginalis. Approximately 11% of infections are found to be co-infections of multiple T. vaginalis strains. Clinical isolates often differ in their adherence to and cytolysis of host cells, underscoring the importance of understanding the effects of TvEV uptake within the parasite population. To address this question our lab observed the effects of EV uptake by T. vaginalis on parasite gene expression. Using RNA-seq, we showed that TvEVs upregulate expression of predicted parasite membrane proteins and identified a novel adherence factor, heteropolysaccharide binding protein (HPB2).

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