Caenorhabditis elegans
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA280828 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcriptomic profile of the homeodomain protein CEH-23 under mitochondrial ETC stress in C. elegans by comparing gene expression profile between isp-1(qm150) vs. ceh-23(ms23);isp-1(qm150) mutants
2017-07-02 | GSE67754 | GEO
Project description:Mild mitochondrial stress can produce positive effects, a phenomenon referred to as \"mitohormesis.\" This process involves activation of signaling pathways such as the mitochondrial unfolded protein response (UPRmt), which helps restore mitochondrial function and has also been linked to improved health and extended lifespan across various model organisms. In C. elegans, mitohormesis can be triggered through several means—including inhibition of the electron transport chain (ETC), reduction in mitochondrial protein translation, or impaired mitochondrial import—all of which can lead to UPRmt-mediated lifespan extension. However, not all triggers of UPRmt result in increased longevity. For instance, while inhibiting ETC complex II strongly activates UPRmt, it has not been associated with lifespan extension. These findings raise the possibility that UPRmt activation alone may not directly promote longevity. In this study, we aim to investigate this complexity by examining how different mitochondrial stressors that induce UPRmt influence the lifespan of C. elegans. We use RNA-sequencing to profile genome-wide transcriptional responses, with the goal of identifying transcriptomic patterns that may clarify the relationship between UPRmt and longevity.
2025-08-31 | E-MTAB-15031 | biostudies-arrayexpress
Project description:Animals integrate metabolic, developmental, and environmental information before committing key resources to reproduction. In C. elegans, adult animals reallocate key fat stores from intestinal cells to the germline via lipoproteins to promote reproduction. I identified the evolutionarily conserved homeodomain transcription factor CEH-60/PBX as a potent regulator of lipid homeostasis, longevity, and stress response pathways. To gain a comprehensive view of CEH-60 transcriptional activity, I profiled the transcriptomes of ceh-60 mutants by mRNA-Seq and identified genome-wide CEH-60 binding sites by ChIP-Seq. These approaches revealed that several homeostatic pathways are directly controlled by the CEH-60 transcription factor. CEH-60 functions cooperatively with UNC-62/MEIS in the intestine to directly activate lipoprotein genes while simultaneously repressing genes involved in stress responses, including the innate immune and oxidative stress responses. Thus in wild-type animals, CEH-60 serves as a molecular switch that promotes reproduction (i.e., lipoproteins) while repressing stress response and longevity pathways. This study identifies a new key regulator of fat metabolism, longevity, and stress response pathways during normal C. elegans development.
2019-04-04 | GSE112979 | GEO
Project description:Animals integrate metabolic, developmental, and environmental information before committing key resources to reproduction. In C. elegans, adult animals reallocate key fat stores from intestinal cells to the germline via lipoproteins to promote reproduction. I identified the evolutionarily conserved homeodomain transcription factor CEH-60/PBX as a potent regulator of lipid homeostasis, longevity, and stress response pathways. To gain a comprehensive view of CEH-60 transcriptional activity, I profiled the transcriptomes of ceh-60 mutants by mRNA-Seq and identified genome-wide CEH-60 binding sites by ChIP-Seq. These approaches revealed that several homeostatic pathways are directly controlled by the CEH-60 transcription factor. CEH-60 functions cooperatively with UNC-62/MEIS in the intestine to directly activate lipoprotein genes while simultaneously repressing genes involved in stress responses, including the innate immune and oxidative stress responses. Thus in wild-type animals, CEH-60 serves as a molecular switch that promotes reproduction (i.e., lipoproteins) while repressing stress response and longevity pathways. This study identifies a new key regulator of fat metabolism, longevity, and stress response pathways during normal C. elegans development.
2019-04-04 | GSE112978 | GEO
Project description:The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. A textbook example is the production of enormous amounts of yolk proteins destined for the nascent oocytes, termed vitellogenesis. We previously identified the rapidly evolving PBC-class Hox-cofactor CEH-60/PBX as necessary for abundant vit transcription in C. elegans. Differential proteomics data shows that all vitellogenin proteins are indeed drastically downregulated in ceh-60 mutant animals and suggest an additional role for CEH-60’s involvement cuticle structure, innate immunity and stress response.
2019-09-25 | PXD013584 | Pride
Project description:Expression data from 2 wildtype and 8 C. elegans ETC mutants
| PRJNA105145 | ENA
Project description:Expression data from C. elegans wdr-23 mutants
| PRJNA296035 | ENA
Project description:The mitochondrial genome of Caenorhabditis elegans has been sequenced
| PRJNA11801 | ENA
Project description:Transgenerational inheritance of mitochondrial stress adaptation in C. elegans
| PRJNA339523 | ENA
Project description:C. elegans fer-1 mutant gene expression profile
| PRJNA117459 | ENA