Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Streptomyces clavuligerus strain:ATCC 27064

ABSTRACT: Producer of clavulanic acid and cephamycin C

PROVIDER: PRJNA28551 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR017398.fastq.gz	Fastqsanger.gz
	SRR139003.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Streptomyces clavuligerus strain:ATCC 27064

Project description:Producer of clavulanic acid and cephamycin C

| PRJNA19249 | ENA

Streptomyces clavuligerus

Project description:Producer of clavulanic acid and cephamycin C

| PRJNA28563 | ENA

Expression data from Streptomyces clavuligerus

Project description:To increase production of the important pharmaceutical compounds, both mutagenesis approaches and rational engineering have been extensively applied. Mutagenesis approaches are most popular in industry, but their effects have not yet been studied very well. Here, we used microarrays to compare the transcriptomes of the S. clavuligerus wild type (ATCC 27064) strain and the DS48802 clavulanic acid high-producer strain, which has been obtained by classical strain improvement (mutagenesis).

2010-11-10 | GSE24033 | GEO

Expression data from Streptomyces clavuligerus

2010-11-10 | E-GEOD-24033 | biostudies-arrayexpress

Transcriptional analysis between Streptomyces clavuligerus ATCC 27064 and a pSCL4- S. clavuligerus mutant

Project description:The objective is to analyze the differential expression between the wild strain and a pSCL4- S. clavuligerus mutant Experiment type Expression profiling by array

2017-10-25 | GSE92399 | GEO

Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.

Project description:Clavulanic acid (CA) is a powerful inhibitor of the beta-lactamases, enzymes produced by bacteria resistants to penicillin and cefalosporin. This molecule is produced industrially by strains of Streptomyces clavuligerus in complex media which carbon and nitrogen resources are supplied by inexpensive compounds still providing high productivity. The genetic production improvement using physical and chemical mutagenic agents is an important strategy in programs of industrial production development of bioactive metabolites. However, parental strains are susceptible to loss of their original productivity due genetic instability phenomenona. In this work, some S. clavuligerus mutant strains obtained by treatment with UV light and with MMS are compared with the wild type (Streptomyces clavuligerus ATCC 27064). The results indicated that the random mutations originated some strains with different phenotypes, most divergent demonstrated by the mutants strains named AC116, MMS 150 and MMS 54, that exhibited lack of pigmentation in their mature spores. Also, the strain MMS 150 presented a larger production of CA when cultivated in semi-synthetics media. Using other media, the wild type strain obtained a larger CA production. Besides, using the modifed complex media the MMS 150 strain showed changes in its lipolitic activity and a larger production of CA. The studies also allowed finding the best conditions for a lipase activity exhibited by wild type S. clavuligerus and the MMS150 mutant.

| S-EPMC3958168 | biostudies-literature

An integrative transcriptomic and proteomic analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus

Project description:Clavulanic acid is a clinically-important secondary metabolite used in treatment of infectious diseases. We aimed to decipher complex regulatory mechanisms acting in clavulanic acid biosynthesis through the analysis of transcriptome- and proteome-wide alterations in an industrial clavulanic acid overproducer Streptomyces clavuligerus, namely DEPA and its wild-type counterpart NRRL3585.

2022-11-02 | PXD032272 | Pride

Streptomyces clavuligerus strain:ATCC 27064

Project description:Streptomyces clavuligerus strain:ATCC 27064 Raw sequence reads

| PRJNA525288 | ENA

Streptomyces clavuligerus strain:ATCC 27064

Project description:Streptomyces clavuligerus strain:ATCC 27064 Genome sequencing

| PRJNA414136 | ENA

Streptomyces clavuligerus strain:ATCC 27064

Project description:Connection of iron homesostasis and antibiotic production in Streptomyces clavuligerus

| PRJNA938016 | ENA