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Mus musculus

ABSTRACT: Metabolic Regulation of Gene Expression by Histone Lysine ß-hydroxybutyrylation [RNA-seq]

PROVIDER: PRJNA285988 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2053210.fastq.gz	Fastqsanger.gz
	SRR2053211.fastq.gz	Fastqsanger.gz
	SRR2053212.fastq.gz	Fastqsanger.gz
	SRR2053213.fastq.gz	Fastqsanger.gz
	SRR2053204.fastq.gz	Fastqsanger.gz

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Metabolic Regulation of Gene Expression by Histone Lysine ß-hydroxybutyrylation [RNA-seq]

Project description:We identified a new type of histone mark-lysine ß-hydroxybutyrylation (Kbhb). This ketone body derived histone mark (Kbhb) was dramatically induced in livers during starvation. To charactize histopne Kbhb: 1) We mapped genomic distributions of histone Kbhb marks (H3K9bhb, H3K4bhb and H4K8bhb) by ChIP-seq in mouse liver. 2) We examined the response of histone Kbhb mark to starvation by carrying out ChIP-seq experiments for H3K9bhb in both "starved" and "fed" mouse liver. 3) We also examined differentially-expressed genes during starvation by carrying out RNA-seq experiments in both "starved" and "fed" mouse liver. By integrating analyses of ChIP-seq and RNA-seq data, we tried to get a correlation between H3K9bhb mark and gene expression in response to starvation. Sequencing was performed on the HiSeq2000 (Illumina).

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