Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human metagenome

ABSTRACT: The microbiome of the diabetic foot ulcer predicts clinical outcomes

PROVIDER: PRJNA287759 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2095550.fastq.gz	Fastqsanger.gz
	SRR2095560.fastq.gz	Fastqsanger.gz
	SRR2095570.fastq.gz	Fastqsanger.gz
	SRR2095580.fastq.gz	Fastqsanger.gz
	SRR2095590.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 377

Similar Datasets

Project description:Saudi Diabetic foot ulcer microbiome "Investigation of the neuropathic and neuroischemic Diabetic Foot Ulcer Microbiome"

| PRJNA494939 | ENA

Gene expression profile as single cell level of chronic diabetic foot ulcers and chronic non-diabetic foot ulcer

Project description:We investigate the changes between diabetic and non-diabetic wound healing process in chronic foot ulcer.

2023-02-01 | GSE223964 | GEO

Single Cell Analysis of Gene expression profile as single cell level of chronic diabetic foot ulcers and chronic non-diabetic foot ulcer Foot Wounds

Project description:We investigate the changes between diabetic and non-diabetic wound healing process in chronic foot ulcer.

2023-10-24 | GSE245703 | GEO

Changes of Granulation Tissue Protein Mass Spectrometry in Foot Wound of Diabetes Mellitus after Negative Pressure wound therapy

Project description:Before and after negative pressure treatment in 3 diabetic foot patients, the granulation tissue of foot ulcer was sampled and analyzed quantitatively by LC-MS /MS method.

2020-08-17 | PXD020929 |

metagenome

Project description:Metagenomics samples from neuropathic diabetic foot ulcer (DFU) Metagenome

| PRJNA506988 | ENA

A global transcriptome analysis of human epidermal keratinocytes upon inhibition of lncRNA WAKMAR1

Project description:Recent study has revealed that long non-coding RNAs (lncRNAs) perform as important regulators of cellular physiology and pathology, which makes them promising therapeutic and diagnostic entities. We found lncRNA WAKMAR1 is significantly down-regulated in wound-edge keratinocytes from venous ulcer and diabetic foot ulcer compared to the normal wounds. To study the genes regulated by WAKMAR1, we transfected lncRNA GapmeRs into human primary epidermal keratinocytes to inhibit its expression. We performed a global transcriptome analysis of keratinocytes upon inhibition of WAKMAR1 using Affymetrix arrays. We performed a global transcriptome analysis of keratinocytes upon inhibition of WAKMAR1 using Affymetrix arrays.

2018-05-26 | GSE114908 | GEO

Transcriptome analysis in the Treatment of Diabetic Foot Ulcer Healing by Tibial Cortex Transverse Distraction

Project description:To investigate mRNA Expression profile and associated signaling pathways in the treatment of diabetic foot ulcer healing by tibial cortex transverse distraction. Methods: Tissue samples were collected from the wound edge before and after the surgery. After reference genome transcriptome sequencing and subsequent bioinformatics analysis, the differentially expressed genes and related pathways were explored, and functional analysis of important genes and pathways was conducted.

2024-10-30 | GSE271701 | GEO

The Role of Fibroblasts in Diabetic Ulcer Healing and the Therapeutic Potential of Platelet-Rich Plasma (PRP): Insights from Single-Cell Sequencing and Animal Models

Project description:Objective: This study aims to investigate the diversity of fibroblasts present in diabetic ulcers and their impact on the wound healing process, as well as to evaluate the effectiveness of Platelet-Rich Plasma (PRP) therapy in the management of diabetic ulcers. Methodology: The single-cell dataset GSE165816 from the GEO database was utilized to analyze DFU-healer and DFU-nonhealer samples in order to evaluate variations in fibroblasts. Functional characteristics of fibroblasts were investigated through analyses of cell communication, transcription factors, and pseudotime analysis. Additionally, a diabetic ulcer rat model was established to compare the therapeutic effects of PRP, followed by histological and transcriptomic sequencing analyses. Result: Single-cell sequencing analysis identified a greater abundance of fibroblasts in the group of diabetic foot ulcer (DFU) patients who exhibited healing. The findings from biological informatics analysis emphasized the critical role of fibroblasts in the wound healing process. Treatment with PRP notably enhanced wound healing in diabetic ulcers in rats, and transcriptomic analysis indicated that gene expression levels post-PRP treatment resembled those of the non-diabetic ulcer group, with a strong association to fibroblasts. Conclusion: Fibroblasts are essential in the process of healing diabetic ulcers, as certain transcription factors have the potential to facilitate wound closure. PRP therapy has been shown to enhance the healing process in diabetic ulcer rat models, possibly through the modulation of gene expression and the promotion of extracellular matrix arrangement. This research offers novel insights and potential therapeutic approaches for managing diabetic ulcers.

2024-11-11 | GSE280992 | GEO

clinical metagenome

Project description:Distribution of microbial communities and core microbiome in successive wound grades of diabetic foot ulcer individuals

| PRJNA596613 | ENA

Human wound bacteria

Project description:Metagenome of diabetic ulcer

| PRJNA300337 | ENA