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Drosophila melanogaster

ABSTRACT: RNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress

OTHER RELATED OMICS DATASETS IN: GSE70591

PROVIDER: PRJNA289117 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2088913.fastq.gz	Fastqsanger.gz
	SRR2088914.fastq.gz	Fastqsanger.gz
	SRR2088915.fastq.gz	Fastqsanger.gz
	SRR2088916.fastq.gz	Fastqsanger.gz

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RNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress

Project description:Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutants are sensitive to the oxidizer paraquat, we also carried out RNA-seq from wildtype and kdm5 mutant adults in oxidative stress conditions. Paraquat treatment of wildtype flies lead to the upregulation of 2481, and downregulation of 3103 genes adult mRNA profiles of 1-3-days old wild type (WT) and kdm5 mutant under normal condition and oxitative stress were generated by deep sequencing, using Illumina HisSeq 2000.

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Project description:KDM5 occupancy and expression profiling of kdm5 mutant flies and wt flies under normal condition and oxidative stress

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RNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress

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Project description:To determine the gene expression changes associated with loss of KDM5 in drosophila intestine tissue, we performed RNA-seq analyses for these dissected intestine tissue from wildtype and kdm5 mutant. These analyses revealed different expressed genes between kdm5 mutant compared to wildtype in intestine tissue. These differentially expressed genes were enriched in the innate immune pathway through Gene ontology(GO) enrichment analysis.

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Project description:To determine microbiota composition associated with loss of KDM5 in intestine, we carried out 16S rRNA seq analyses of dissected intestine from wildtype and kdm5 mutant. [GSM2628181-GSM2628190]. A total of 78 operational taxonomic units (OTUs) were identified in the sequence data. There were about 15 genera much less abundant in kdm5 mutant compared to wildtype. The kdm5 mutant were sensitive to pathogen. To confirm the microbiota associated with loss of KDM5 in intestine, 16S rRNA of new flies were sequenced and analyzed by Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China) [GSM3243472-GSM3243481]. A total of 107 operational taxonomic units (OTUs) were identified in the sequence data. There were about 20 genera much less abundant in kdm5 mutant compared to wildtype. To confirm the microbiota associated with loss of KDM5 drosophila feeding with Lactobacillus plantarum, 16S rRNA of kdm5 mutant flies were sequenced and analyzed by Novogene Bioinformatics Technology Co., Ltd. (Tianjin, China) [GSM3263522-GSM3263527]. A total of 92 operational taxonomic units (OTUs) were identified in the sequence data. To confirm the microbiota associated with KDM5 knockdown in intestine, 16S rRNA of Myo1A-Gal4TS/+ and Myo1A-Gal4TS/+;+/kdm5RNAi flies were sequenced and analyzed by Biomarker Co. Ltd. (Beijing, China). [GSM3507915-GSM3507924]. A total of 50 operational taxonomic units (OTUs) were identified in the sequence data. There was a significant different based on the genus level between two groups.

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