Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Myotis lucifugus

ABSTRACT: Myotis lucifugus Phenotype or Genotype

PROVIDER: PRJNA291858 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2124152.fastq.gz	Fastqsanger.gz
	SRR2135901.fastq.gz	Fastqsanger.gz
	SRR2135823.fastq.gz	Fastqsanger.gz
	SRR2135794.fastq.gz	Fastqsanger.gz
	SRR2141970.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 350

Similar Datasets

Myotis lucifugus lucifugus

Project description:Myotis lucifugus lucifugus Raw sequence reads

| PRJNA392352 | ENA

Myotis lucifugus

Project description:Myotis lucifugus Raw sequence reads

| PRJNA277738 | ENA

Myotis lucifugus

Project description:Myotis lucifugus Transcriptome or Gene expression

| PRJNA218522 | ENA

Myotis lucifugus

Project description:Myotis lucifugus MHC II DRB sequencing

| PRJNA305905 | ENA

Myotis lucifugus

Project description:Myotis lucifugus Transcriptome or Gene expression

| PRJNA170650 | ENA

Myotis lucifugus

Project description:Myotis lucifugus whole exome target-capture raw sequence reads

| PRJNA633086 | ENA

Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells (CUT&RUN)

Project description:Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed bat-specific adaptations affecting interferon (IFN) signaling and IFN-stimulated genes (ISGs), but we still have a limited understanding of the genetic mechanisms that have shaped the evolution of bat immunity. Here we investigated the transcriptional and epigenetic dynamics of transposable elements (TEs) during the type I IFN response in little brown bat (Myotis lucifugus) primary embryonic fibroblast cells, using RNA-seq and CUT&RUN. We found multiple bat-specific TEs that undergo both locus-specific and family-level transcriptional upregulation in response to IFN. Our transcriptome reassembly identified multiple ISGs that have acquired novel exons from bat-specific TEs, including NRLC5, SLNF5 and a previously unannotated isoform of the IFITM2 gene. We also identified examples of TE-derived regulatory elements, but did not find strong evidence supporting genome-wide epigenetic activation of TEs in response to IFN. Collectively, our study uncovers numerous TE-derived transcripts, proteins, and alternative isoforms that are induced by IFN in Myotis lucifugus cells, highlighting potential candidate loci that contribute to bat-specific immune function.

2022-04-21 | GSE200831 | GEO

Plasma proteomic profile differences between healthy and white-nose affected Myotis lucifugus

Project description:We compared the proteomic profile of blood plasma in healthy and white-nose syndrome affected Myotis lucifugus in order to identify patho-physiological changes associated with the disease. Using two-dimensional gel electrophoresis and liquid chromatography-mass spectrometry we identified differentially expressed proteins for acute phase response, constitutive and adaptive immunity, oxidative stress defense, metabolism and structural proteins of exosomes and desmosomes, suggesting a systemic response against Pseudogymnoascus destructans infection in a North American bat species.

2020-04-09 | PXD018142 | Pride