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The human glioblastoma cell culture resource

ABSTRACT: The human glioblastoma cell culture resource

PROVIDER: PRJNA293382 | ENA |

REPOSITORIES: ENA

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CNA data from The human glioblastoma cell culture resource: validated cell models representing all molecular subtypes

Project description:To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and validated cell lines derived from surgical samples of GBM patients, maintained under conditions to preserve GSC characteristics. This collection, which we call the Human Glioblastoma Cell Culture (HGCC) resource, consists of a biobank of GC lines and an associated database containing high-resolution molecular data.

2015-08-20 | GSE72209 | GEO

Expression data from The human glioblastoma cell culture resource: validated cell models representing all molecular subtypes (exon)

2015-08-20 | GSE72217 | GEO

Epigenomic profiling of patient-derived GBM cell lines obtained from GBM patient surgical samples (HGCC resource)

Project description:The recent incorporation of molecular features into the diagnosis of Glioblastoma Multiforme patients has led to an improved categorisation into different tumour subtypes with different prognosis and disease management. In this work, we have exploited the benefits of genome-wide multiomic approaches to identify potential molecular vulnerabilities existing on GBM patients. We used the Illumina MethylationEPIC Beadchip platform to describe the genome-wide 5mC and 5hmC DNA methylation landscape of a total of 9 patient-derived Glioblastoma Multiforme Cell lines obtained from the human glioblastoma cell culture resource (HGCC) and 4 brain samples obtained from non-tumoral controls

2023-06-01 | E-MTAB-12473 | biostudies-arrayexpress

human culture cell and mouse culture cell

Project description:human culture cell and mouse culture cell Targeted Locus (Loci)

| PRJNA420401 | ENA

The human glioblastoma cell culture resource

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-20 | GSE72219 | GEO

Human Developmental Biology Resource (HDBR) expression resource-RNAseq

Project description:Human Developmental Biology Resource (HDBR) expression resource-RNAseq

| PRJEB14594 | ENA

Expression data from "A patient-derived cell atlas of glioblastoma informs precision targeting of the proteasome" (Johansson et al, Cell Reports, 2020)

Project description:We analysed gene expression levels in a panel of pharmacologically patient derived glioblastoma cell lines. The purpose of the experiment was to provide gene expression data for predictive modeling of drug responses. For more information about the Human Glioma Cell Culture (HGCC) resource, see portal.hgcc.se.

2020-07-14 | GSE152160 | GEO

Ameloblastoma cell line resource

Project description:Ameloblastoma cell line resource

| PRJNA792009 | ENA

Ameloblastoma cell line resource

Project description:Ameloblastoma cell line resource

| PRJNA791980 | ENA

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.

Project description:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and validated cell lines derived from surgical samples of GBM patients, maintained under conditions to preserve GSC characteristics. This collection, which we call the Human Glioblastoma Cell Culture (HGCC) resource, consists of a biobank of 48 GC lines and an associated database containing high-resolution molecular data. We demonstrate that the HGCC lines are tumorigenic, harbor genomic lesions characteristic of GBMs, and represent all four transcriptional subtypes. The HGCC panel provides an open resource for in vitro and in vivo modeling of a large part of GBM diversity useful to both basic and translational GBM research.

| S-EPMC4634360 | biostudies-literature

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