Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Master transcription factors in corneal epithelial cells [ChIP-seq]

PROVIDER: PRJNA294532 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2229592.fastq.gz	Fastqsanger.gz
	SRR2229593.fastq.gz	Fastqsanger.gz
	SRR3223079.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Homo sapiens

Project description:Master transcription factors in corneal epithelial cells [ATAC-Seq]

| PRJNA281650 | ENA

Homo sapiens

Project description:Master transcription factors in corneal epithelial cells [in vivo samples]

| PRJNA281001 | ENA

Homo sapiens

Project description:Master transcription factors in corneal epithelial cells [OVOL2 Knock-down]

| PRJNA315282 | ENA

Homo sapiens

Project description:Master transcription factors in corneal epithelial cells [6TFs transduced experimental samples]

| PRJNA281003 | ENA

Master transcription factors in corneal epithelial cells

Project description:Master transcription factors in corneal epithelial cells

| PRJNA280994 | ENA

Mus musculus

Project description:Master transcription factors in corneal epithelial cells [OVOL2 transduced experimental samples]

| PRJNA281002 | ENA

Genome-wide analysis of histone modifications H3K4me3, H3K4me1, and H3K27ac in primary human corneal epithelial cells

Project description:The corneal epithelium is a stratified squamous epithelium that protects the eye from mechanical and toxic stress. In this system, cells are continually being sloughed off from the surface of the eye, and replenished by proliferation from corneal stem cells in the limbus, which migrate in and differentiate. During tissue development and homeostasis, distal regulatory regions called enhancers, which contain binding sites for numerous transcription factors, help to control and coordinate gene expression in a temporal and spatial specific manner. To identify enhancers in cornea epithelia, we performed ChIP-Seq with antibodies to the histone marks H3K4me3, H3K4me1, and H3K27ac in primary human corneal epithelial cells. Active enhancers were defined as having high levels of H3K4me1 and H3K27ac, and low levels of H3K4me3: 12,900 such regions were identified in the corneal epithelial cells. In combination with primary cell histone modification ChIP-Seq data from BROAD, 2946 active enhancer regions were identified that are unique to the corneal epithelial cells: 1551 of theses 2946 also overlie regions of high evolutionary constraint. Motif enrichment analysis of these regions has revealed binding sites for a number of transcription factors, highlighting their roles as key regulators of corneal epithelial development.

2017-06-01 | GSE43499 | GEO

Homo sapiens

Project description:BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment [ChIP-seq]

| PRJNA315416 | ENA

Homo sapiens

Project description:ChIP-seq of RNA polymerase II, transcription factors and histone modification in retinal pigment epithelial cells

| PRJNA257297 | ENA

Homo sapiens

Project description:ChIP-seq of the HOXA9 and MEIS1 transcription factors in SEM cells.

| PRJNA167740 | ENA