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Homo sapiens

ABSTRACT: 82-kDa ChAT and SATB1 ChIP-seq after vehicle or amyloid-beta exposure

PROVIDER: PRJNA297352 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2537143.fastq.gz	Fastqsanger.gz
	SRR2537144.fastq.gz	Fastqsanger.gz
	SRR2537145.fastq.gz	Fastqsanger.gz
	SRR2537146.fastq.gz	Fastqsanger.gz
	SRR2537147.fastq.gz	Fastqsanger.gz

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82-kDa ChAT and SATB1 ChIP-seq after vehicle or amyloid-beta exposure

Project description:Using chromatin immunoprecipitation and next-generation sequencing (ChIP-seq), we assessed the effects of acute exposure to oligomeric amyloid-beta on 82-kDa ChAT and SATB1 genome association in human SH-SY5Y neural cells, finding that Aβ-exposure increased 82-kDa ChAT and SATB1 association with gene promoters, introns and matrix attachment regions. We found that both SATB1 and 82-kDa ChAT associate with synapse and cell stress related genes after amyloid-beta exposure.

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