Macaca mulatta
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA297766 | ENA |
REPOSITORIES: ENA
Similar Datasets
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Project description:Aging is a major risk factor for various forms of disease. An enhanced understanding of the physiological mechanisms related to aging is urgently needed. Nonhuman primates (NHPs) have the closest genetic relationship to humans, making them an ideal model to explore the complicated aging process. Multiomics analysis of NHP peripheral blood offers a promising approach to evaluate new therapies and biomarkers. Here, we explored the mechanisms of aging using proteomics (serum and serum-derived exosomes [SDEs]) in rhesus monkey (Macaca mulatta) blood.
2024-06-22 | PXD030287 | Pride
Project description:Aging is a major risk factor for various forms of disease. An enhanced understanding of the physiological mechanisms related to aging is urgently needed. Nonhuman primates (NHPs) have the closest genetic relationship to humans, making them an ideal model to explore the complicated aging process. Multiomics analysis of NHP peripheral blood offers a promising approach to evaluate new therapies and biomarkers. Here, we explored the mechanisms of aging using proteomics (serum) in rhesus monkey (Macaca mulatta) blood.
2024-06-22 | PXD030289 | Pride
Project description:Graft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD (GSE73723). Within these profiles we discovered potentially druggable targets not previously implicated in GVHD, prominently including aurora kinase A (AURKA). In this study, we performed a planned comparison of AURKA gene expression in HCT-recipients with clinical GVHD and compared it to expression in HCT-recipients without clinical GVHD.
2015-11-29 | GSE73809 | GEO
Project description:Gene expression of lung tissues in non-human primate (NHP, rhesus macaque) after exposure to thoracic irradiation
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Project description:The purpose of the experiment was to compare placental transcriptome of rhesus macaque at approximately 80% completed gestation to human placental transcriptomes.
2018-08-09 | GSE118284 | GEO
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Project description:Rhythms of life on earth are shaped by the seasons. Accordingly, various physiological functions such as hormonal secretion, metabolism, growth, immune function, and reproduction show profound seasonal changes in animals including humans. Morbidity in humans due to cardiovascular disease, influenza, and psychiatric diseases is also seasonally regulated and peaks in winter. However, their underlying molecular bases remain unknown. Non-human primates (NHPs) represent the nearest-to-human alternative and are crucial to understand human physiology and diseases. In this study, we identifed genes that showed seasonal oscillations in the expressions for each of the 80 tissues, including 30 brain regions and 50 peripheral tissues collected every 2 months from male and female NHP rhesus macaques (Macaca mulatta) that were kept under seminatural outdoor conditions. In addition, the seasonal transcriptome partterns can be checked in our web database entitled “Non-Human Primate Seasonal Transcriptome Atlas (NHPSTA)”. The overall study contributes to our understanding of the molecular basis for seasonally regulated physiological mechanisms and provides potential biomarkers and targets for developing novel therapeutic intervention for seasonally regulated diseases.
2025-02-01 | GSE201986 | GEO