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Canis lupus familiaris

ABSTRACT: Transcriptome analysis in MDCK cells on anti-influenza A activity of bakuchiol

PROVIDER: PRJNA297808 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2559390.fastq.gz	Fastqsanger.gz
	SRR2559391.fastq.gz	Fastqsanger.gz
	SRR2559392.fastq.gz	Fastqsanger.gz
	SRR2559393.fastq.gz	Fastqsanger.gz
	SRR2559388.fastq.gz	Fastqsanger.gz

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Canis lupus familiaris

Project description:Transcriptome analysis in MDCK cells on anti-influenza A activity of bakuchiol

| PRJDB3863 | ENA

Transcriptome analysis in MDCK cells on anti-influenza A activity of bakuchiol

Project description:Bakuchiol is a phenolic isoprenoid compound present in Babchi (Psoralea corylifolia Linn.) seeds. We examined the anti-influenza activity of synthetic bakuchiol using Madin-Darby canine kidney (MDCK) cells. We found that the naturally occurring form, (+)-(S)-bakuchiol, and its enantiomer, (-)-(R)-bakuchiol, inhibited influenza A infection and growth, and reduced the expression of viral mRNAs and proteins in MDCK cells. However, the molecular mechanism in anti-influenza activity of bakuchiol remains unclear. Thus, to evaluate its molecular mechanism in host cells, we performed the next generation sequencing analysis of the MDCK transcriptome in cells treated with bakuchiol and influenza A/PR/8/34. These results provide keys to elucidate the molecular mechnism of anti-influenza activity of bakuchiol for us, and these data will contribute to the development of novel approaches to anti-influenza treatments.

2015-10-06 | GSE73750 | GEO

Canis lupus familiaris

Project description:Host cell gene expression in Influenza A/WSN/33 (H1N1) infected MDCK cells at 10 hour post infection

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Project description:Host cell gene expression in Influenza A/WSN/33 (H1N1) infected MDCK cells at 2, 4 and 6 hours post infection

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Project description:Host cell gene expression in Influenza A/duck/Malaysia/F59/04/1998 (H5N2) infected MDCK cells at 10 hour post infection

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Project description:Host cell gene expression in Influenza A/duck/Malaysia/F189/07/2004 (H5N2) infected MDCK cells at 10 hour post infection

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Project description:Expression data from MDCK cells exposed to HGF +/- MAPK inhibitors

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