Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA300841 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:In vitro microRNA screening in human pancreatic adenocarcinoma
| PRJNA300842 | ENA
Project description:microRNA expression in lung squamous cell carcinoma cell lines
| PRJNA297888 | ENA
Project description:MicroRNA deregulation in laryngeal squamous cell carcinoma cell lines
| PRJNA296079 | ENA
Project description:No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma. MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. This study assesses chemoresistant PDAC for its specific miR expression pattern. Gemcitabine-resistant variants of two mutant p53 human pancreatic adenocarcinoma cell lines were established. MicroRNA screening was investigated by microarray.
2015-11-03 | GSE74565 | GEO
Project description:RNA sequencing of human pancreatic cancer cell lines
| PRJNA316672 | ENA
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
2010-09-25 | GSE24338 | GEO
Project description:We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3’ and/or 5’ end of the miRNA. Northern blotting for individual miRNAs showed that the proportions of isomiRs expressed by a single miRNA gene often differ between cell and tissue types. IsomiRs were readily co-immunoprecipitated with Argonaute proteins in vivo and were active in luciferase assays, indicating that they are functional. Bioinformatics analysis predicts substantial differences in targeting between miRNAs with minor 5’ differences and in support of this we report that a 5’ isomiR-9-1 gained the ability to inhibit the expression of DNMT3B and NCAM2 but lost the ability to inhibit CDH1 in vitro. This result was confirmed by the use of isomiR-specific sponges. Our analysis of the miRGator database indicates that a small percentage of human miRNA genes express isomiRs as the dominant transcript in certain cell types and analysis of miRBase shows that 5’ isomiRs have replaced canonical miRNAs many times during evolution. This strongly indicates that isomiRs are of functional importance and have contributed to the evolution of miRNA genes
2014-08-06 | GSE58734 | GEO
Project description:Crispr Screening -sequencing results for pancreatic cancer cell lines treated with chemotherapeutic drugs
| PRJNA542321 | ENA
Project description:Human esophageal squamous cell carcinoma cell lines with downregulated PTTG1
| PRJNA100221 | ENA