Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hepatitis delta virus

ABSTRACT: Hepatitis delta virus sequencing (360-bp)

PROVIDER: PRJNA308541 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3655310.fastq.gz	Fastqsanger.gz
	SRR3655320.fastq.gz	Fastqsanger.gz
	SRR3655330.fastq.gz	Fastqsanger.gz
	SRR3655340.fastq.gz	Fastqsanger.gz
	SRR3659190.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 76

Similar Datasets

Hepatitis delta virus

Project description:Hepatitis delta virus Phenotype or Genotype

| PRJNA635701 | ENA

Hepatitis delta virus

Project description:Hepatitis delta virus Raw sequence reads

| PRJNA798886 | ENA

Hepatitis delta virus

Project description:Hepatitis delta virus high-throughput sequencing of the right region of genomic HDV RNA

| PRJNA190190 | ENA

Hepatitis delta virus

Project description:Viral escape mutations in HLA-B*27-restricted epitopes correlate with a chronic hepatitis delta virus infection.

| PRJNA434630 | ENA

Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

Project description:Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected cells by cellular RNA polymerases with the assistance of the small hepatitis delta antigen (S-HDAg). Here we show that S-HDAg binds the Bromodomain (BRD) Adjacent To Zinc Finger Domain 2B (BAZ2B) protein, a regulatory subunit of BRF (BAZ2B-Associated Remodeling Factor) ISWI chromatin remodeling complexes. ShRNAs-mediated silencing of BAZ2B or its inactivation with the BAZ2B-BRD inhibitor GSK-2801 impairs HDV replication in HDV-infected human hepatocytes. S-HDAg contains a short linear interacting motif (SLiM) KacXXR, similar to the one recognized by BAZ2B-BRD in histone H3. We found that the integrity of the S-HDAg SLiM sequence is required for S-HDAg interaction with BAZ2B-BRD and for HDV RNA replication. Our results suggest that S-HDAg uses a histone mimicry strategy to co-activate the RNA Polymerase II-dependent synthesis of HDV RNA and sustain HDV replication.

2020-05-27 | PXD016880 | Pride

Hepatitis B virus

Project description:Hepatitis B virus Genome sequencing

| PRJNA625435 | ENA

hepatitis B virus

Project description:hepatitis B virus Genome sequencing

| PRJNA289733 | ENA

Hepatitis B virus

Project description:Hepatitis B virus Genome sequencing

| PRJNA944979 | ENA

Hepatitis B virus

Project description:Hepatitis B virus Genome sequencing