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Streptococcus pneumoniae TIGR4

ABSTRACT: Differential transcription of small RNAs and mRNAs of Streptococcus pneumoniae TIGR4 when grown with the biofilm inhibitor Carolacton

PROVIDER: PRJNA309178 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3106600.fastq.gz	Fastqsanger.gz
	SRR3106610.fastq.gz	Fastqsanger.gz
	SRR3106620.fastq.gz	Fastqsanger.gz
	SRR3106630.fastq.gz	Fastqsanger.gz
	SRR3106601.fastq.gz	Fastqsanger.gz

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Differential transcription of small RNAs and mRNAs of Streptococcus pneumoniae TIGR4 when grown with the biofilm inhibitor Carolacton

Project description:Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans in nanomolar concentrations. Interestingly, Carolacton also inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4. The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when S. pneumoniae TIGR4 was grown in the presence of Carolacton. This was done to identify transcriptional regulatory networks that are directly affected by treatment of the pneumococcus with Carolacton. In order to gain insights into the primary transcriptional response, early time-points were chosen for sampling, which should not reflect secondary responses (e.g. due to differences in growth phase, drop in pH etc.). To achieve a thorough overview over all affected cellular RNA species, such as mRNAs, small regulatory RNAs and tRNAs, and not to lose small transcripts during library preparation, RNAs were separated according to size and used to construct two separate libraries for sequencing.

2016-09-19 | GSE76979 | GEO

Transcriptomal changes of Escherichia coli TolC grown with the biofilm inhibitor Carolacton

Project description:Carolacton is a novel biofilm inhibitor that kills biofilm cells of Streptococcus mutans and inhibits growth of the clinically relevant and human pathogenic bacterium Streptococcus pneumoniae TIGR4 in nanomolar concentrations. Interestingly, Carolacton also inhibits Escherichia coli with a defective outer membrane protein TolC . The cellular target of Carolacton is still unknown. Here, we adressed the differential transcription of cellular RNAs when E.coli TolC was grown in the presence of Carolacton. This was done to identify transcriptional regulatory networks that are directly affected by treatment of the strain with Carolacton. In order to gain insights into the primary transcriptional response, early time-points were chosen for sampling, which should not reflect secondary responses (e.g. due to differences in growth phase, nutrient depletion etc.).

2017-02-15 | GSE93125 | GEO

Kinetic analysis of carolacton-regulated genes

Project description:Transcriptional profiling of carolacton-treated Streptococcus mutans biofilm cells in comparison to untreated biofilms in a time series approach.

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Streptococcus pneumoniae TIGR4

Project description:Streptococcus pneumoniae TIGR4 Epigenomics

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Kinetic analysis of carolacton-regulated genes

Project description:Transcriptional profiling of carolacton-treated Streptococcus mutans biofilm cells in comparison to untreated biofilms in a time series approach. Two-condition times series experiment, carolacton treated vs. untreated for timepoints 5, 20, 40, 60, 80, 100, 120, 160, 200, 240 and 300 minutes post-carolacton addition, 2 technical replicates of each sample (dye swap).

2014-02-13 | E-GEOD-53264 | biostudies-arrayexpress

Streptococcus pneumoniae TIGR4

Project description:Streptococcus pneumoniae TIGR4 Genome sequencing

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Project description:Streptococcus pneumoniae TIGR4 Genome sequencing

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RNA-seq analysis of transport deficient S. pneumoniae TIGR4 mutants

Project description:The polyamine transport operon in Streptococcus pneumoniae TIGR4 is necessary for survival in murine models of pneumococcal pneumonia. To date, there is no description of polyamine transport dependent pneumococcal gene expression. In this study, we compared gene expression between the wild-type and transport deficient (potABCD) TIGR4 by RNA-Seq analysis.

2017-08-14 | E-MTAB-5951 | biostudies-arrayexpress

Streptococcus pneumoniae TIGR4

Project description:Streptococcus pneumoniae TIGR4 Raw sequence reads

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Impact of impaired polyamine biosynthesis on Streptococcus pneumoniae TIGR4 gene expression

Project description:The polyamine biosynthesis gene, speE, in Streptococcus pneumoniae TIGR4 is necessary for survival in murine models of pneumococcal pneumonia. To date, there is no description of polyamine biosynthesis dependent pneumococcal gene expression. In this study, we compared gene expression between the wild-type and biosynthesis deficient (speE) TIGR4 by RNA-Seq analysis.

2023-01-01 | E-MTAB-6070 | biostudies-arrayexpress

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