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Mus musculus

ABSTRACT: PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [RNA-Seq]

PROVIDER: PRJNA310130 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3132830.fastq.gz	Fastqsanger.gz
	SRR3132840.fastq.gz	Fastqsanger.gz
	SRR3132850.fastq.gz	Fastqsanger.gz
	SRR3132860.fastq.gz	Fastqsanger.gz
	SRR3132870.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [ChIP-Seq]

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PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells

Project description:PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells

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PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [ChIP-Seq]

Project description:Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its mechanism of action is highly relevant from a therapeutic perspective. Our current understanding of the role of PROP1 in the pituitary gland is limited to the regulation of pituitary transcription factors Hesx1 and Pit1. To elucidate the comprehensive PROP1-dependent gene regulatory network, we conducted genome wide analysis of PROP1 DNA binding and effects on gene expression in mutant tissues, isolated stem cells and engineered cell lines. We determined that PROP1 is essential for maintaining proliferation of stem cells and stimulating them to undergo an epithelial to mesenchymal transition-like process necessary for cell migration and differentiation. Genomic profiling reveals that PROP1 binds to and represses claudin 23, characteristic of epithelial cells, and it activates EMT inducer genes: Zeb2, Notch2 and Gli2. Our findings identify PROP1 as a central transcriptional component of pituitary stem cell differentiation.

2016-07-11 | GSE77302 | GEO

PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [RNA-Seq]

2016-07-11 | GSE77357 | GEO

Mus musculus

Project description:Gene expression in epithelial, EMT (epithelial-mesenchymal transition) and MET (mesenchymal-epithelial transition) cells

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Mus musculus

Project description:MAP3K4/CBP Regulated H2B acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells

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Mus musculus

Project description:Genome-scale epigenetic reprogramming during epithelial to mesenchymal transition

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Mus musculus

Project description:Role of TERRA lncRNA during epithelial-to-mesenchymal transition

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Mus musculus

Project description:Erk-dependent Epigenetic Reprogramming Underlies Epithelial to Mesenchymal Transition

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PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression

Project description:Dietary vitamin A is metabolized into bioactive retinoic acid in vivo and regulates the development of many embryonic tissues. Retinoic acid signaling is active in the oral ectoderm-derived tissues of the neuroendocrine system, but its role there has not yet been fully explored. We show here that retinoic acid signaling is active during pituitary organogenesis and dependent on the pituitary transcription factor Prop1. Prop1-mutant mice show reduced expression of the aldehyde dehydrogenase gene Aldh1a2, which metabolizes the vitamin A-intermediate retinaldehyde into retinoic acid. In order to elucidate the specific function of RA signaling during neuroendocrine development, we studied a conditional deletion of Aldh1a2 and a dominant-negative mouse model of inhibited retinoic acid signaling during pituitary organogenesis. These models partially phenocopy Prop1-mutant mice by exhibiting embryonic pituitary dysmorphology and reduced hormone expression, especially of thyroid-stimulating hormone. These findings establish the critical role of retinoic acid in embryonic pituitary stem cell progression to differentiated hormone cells and raise the question of gene-by-environment interactions as contributors to pituitary development and disease.

2020-02-26 | GSE142074 | GEO

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