Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Identification of long noncoding RNAs regulated by p53

PROVIDER: PRJNA315294 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3228430_1.fastq.gz	Fastqsanger.gz
	SRR3228430_2.fastq.gz	Fastqsanger.gz
	SRR3228440_1.fastq.gz	Fastqsanger.gz
	SRR3228440_2.fastq.gz	Fastqsanger.gz
	SRR3228431_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Homo sapiens

Project description:Identification of unstable nuclear long noncoding RNAs upon Salmonella infection

| PRJDB3997 | ENA

Homo sapiens

Project description:Identification of long noncoding RNAs in T-ALL cell lines

| PRJNA400047 | ENA

Homo sapiens

Project description:Identification and functional characterization of long noncoding RNAs in breast cancer

| PRJNA266932 | ENA

Homo sapiens

Project description:Identification of genes regulated by Long noncoding RNA H19 in hepatic cells

| PRJNA400482 | ENA

Homo sapiens

Project description:Long-noncoding RNAs in basal cell carcinoma

| PRJNA301686 | ENA

Homo sapiens

Project description:Identification of Dysregulated Long Noncoding RNAs in the Midbrain of Human Cocaine Abusers

| PRJNA279408 | ENA

Homo sapiens

Project description:Identification of heat shock-induced noncoding RNAs

| PRJDB3999 | ENA

Homo sapiens

Project description:Senescence-associated lncRNAs: senescence-associated long noncoding RNAs.

| PRJNA311196 | ENA

Homo sapiens

Project description:Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma

| PRJNA100443 | ENA

Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage

Project description:The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptome-wide differential expression analysis, genome-wide p53 binding profiles, chromatin state maps, and additional genomic features to characterize the global regulatory roles of p53 in response to DNA damage in both human and mouse fibroblast models. In addition to known p53 targets, we identify many previously unappreciated mRNAs and long noncoding RNAs that are regulated by p53. Moreover, we find that p53 binding events occur predominantly within enhancer elements in both human and mouse systems. The ability to modulate enhancer activity offers an additional layer of complexity to the p53 network and greatly expands the diversity of genomic elements that are directly regulated by p53. Human and Mouse fibroblasts cultured in the presence or absence of doxorubicin followed by RNA-Seq (Human:2 cell lines, each condition in duplicate; Mouse:MEF cell line,each condition in triplicate) and p53 ChIP-Seq (Human:2 cell lines, input and IP for each; Mouse:MEF cell line, input and IP)

2015-04-18 | E-GEOD-55727 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data