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Mus musculus

ABSTRACT: Microglia development follows a stepwise program to regulate brain homeostasis - Single Cell RNA-seq

PROVIDER: PRJNA317060 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11004730.fastq.gz	Fastqsanger.gz
	SRR11004731.fastq.gz	Fastqsanger.gz
	SRR11004732.fastq.gz	Fastqsanger.gz
	SRR11004733.fastq.gz	Fastqsanger.gz
	SRR11004734.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:Microglia development follows a stepwise program to regulate brain homeostasis - RNA seq

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Mus musculus

Project description:Microglia development follows a stepwise program to regulate brain homeostasis - ChIP-seq

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Microglia development follows a stepwise program to regulate brain homeostasis

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Microglia development follows a stepwise program to regulate brain homeostasis - Single Cell RNA-seq

Project description:Microglia play important roles in life-long brain maintenance and in pathology, but are also crucial in the developing central nervous system; yet their regulatory dynamics during development have not been fully elucidated. Genome-wide chromatin and expression profiling coupled with single-cell transcriptomic analysis throughout development reveal that microglia undergo three temporal developmental stages in synchrony with the brain: early, pre-, and adult microglia, which are under the control of distinct regulatory circuits. Knockout of the transcription factor MafB caused disruption of homeostasis in adulthood and increased inflammation. Environmental perturbations, such as the microbiome or prenatal immune activation, led to dysregulation of the developmental program, particularly in terms of inflammation. Together, our work identifies a stepwise developmental program of microglia integrating immune response pathways that may be associated with several neurodevelopmental disorders.

2016-07-13 | GSE79818 | GEO

Microglia development follows a stepwise program to regulate brain homeostasis - ChIP-seq

2016-07-13 | GSE79816 | GEO

Microglia development follows a stepwise program to regulate brain homeostasis - RNA seq

2016-07-13 | GSE79812 | GEO

Expression data from mus musculus subjected to traumatic brain injury (TBI) for treatment with cyclophosphamide

2014-06-14 | GSE58484 | GEO

Single-cell RNA-seq of rat microglia in monoculture and in coculture with neurons and astrocytes

Project description:Microglia, brain resident macrophages, require instruction from the central nervous system microenvironment to maintain their identity, morphology, and to regulate inflammatory responses. We investigated the heterogeneity of response of microglia to the presence of neurons and astrocytes by performing single-cell sequencing of microglia in both monoculture, and in coculture with neurons and astrocytes.

2021-03-23 | E-MTAB-10030 | biostudies-arrayexpress

Expression data from chemokine-deficient mus musculus subjected to traumatic brain injury (TBI)

Project description:We inflicted TBI to chemokine-deficient mouse lines in order to establish involvement of various signalling pathways that may be addressed therapeutically. Interacting chemokine pathways in brain regulate distinct inflammatory cells. Activated microglia are separate from invading phagocytes and dendritic cells. Findings show potential targets to interfere with specific inflammatory responses after brain injury. TBI was carried out in Ccl3-/- and Ccr2-/- mice, total RNA prepared from injured cerebral neocortex after three days. RNA samples were from uninjured Ccl3-/- and Ccr2-/- mice as reference for hybridization on Affymetrix microarrays.

2014-06-14 | E-GEOD-58483 | biostudies-arrayexpress

Expression data from mus musculus subjected to traumatic brain injury (TBI) for treatment with cyclophosphamide

Project description:We inflicted TBI to wildetype (wt) mice in order to establish whether the anti-inflammatory agent cyclophosphamide can be used therapeutically. Cyclophosphamide was found to regulate distinct inflammatory cells such as activated microglia separate from invading phagocytes and dendritic cells. Cyclophosphamide postinjury selectively reduces antigen-presenting dendritic cells. Findings show feasibility of drug development to interfere with brain inflammation. TBI was carried out in injured wt B6 mice for postinjury treatment with cyclophospamide i.p. using saline as a control substance for comparison with injured but untreated mice. Total RNA was prepared from injured cerebral neocortex after three days. RNA samples were also from uninjured wt mice as reference for hybridization on Affymetrix microarrays.

2014-06-14 | E-GEOD-58484 | biostudies-arrayexpress

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