Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA318407 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR3380690_1.fastq.gz | Fastqsanger.gz | |||
| SRR3380690_2.fastq.gz | Fastqsanger.gz | |||
| SRR3380700_1.fastq.gz | Fastqsanger.gz | |||
| SRR3380700_2.fastq.gz | Fastqsanger.gz | |||
| SRR3380710_1.fastq.gz | Fastqsanger.gz |
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Project description:In this study, we characterize the fusion protein produced by the EPC1-PHF1 translocation in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We express the fusion protein and necessary controls in K562 Cells. The fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression.
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