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Rattus norvegicus

ABSTRACT: Transcriptome response to endoplasmic reticulum stress in rat oligodendrocyte precursor cells

PROVIDER: PRJNA322543 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3575030.fastq.gz	Fastqsanger.gz
	SRR3575021.fastq.gz	Fastqsanger.gz
	SRR3575031.fastq.gz	Fastqsanger.gz
	SRR3575022.fastq.gz	Fastqsanger.gz
	SRR3575032.fastq.gz	Fastqsanger.gz

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Project description:Oligodendrocytes undergo extensive changes as they differentiate from progenitors into myelinating cells. To better understand the; molecular mechanisms underlying this transformation, we performed a comparative analysis using gene expression profiling of A2B5+; oligodendrocyte progenitors and O4+ oligodendrocytes. Cells were sort-purified ex vivo from postnatal rat brain using flow cytometry. Using Affymetrix microarrays, 1707 transcripts were identified with a more than twofold increase in expression inO4+oligodendrocytes. Many genes required for oligodendrocyte differentiation were upregulated in O4+ oligodendrocytes, including numerous genes encoding; myelin proteins. Transcriptional changes included genes required for cell adhesion, actin cytoskeleton regulation, and fatty acid and; cholesterol biosynthesis. At the O4+ stage, there was an increase in expression of a novel proline-rich transmembrane protein (Prmp). Localized to the plasma membrane, Prmp displays adhesive properties that may be important for linking the extracellular matrix to the; actin cytoskeleton. Together, our results highlight the usefulness of this discovery-driven experimental strategy to identify genes relevant; to oligodendrocyte differentiation and myelination. Experiment Overall Design: Whole brain dissociates were prepared from one litter of 10 male postnatal day 7 rat pups for each of the 5 A2B5 bioligcal replicates and the 4 O4+ bioligical replicates. Total RNA was extracted from single A2B5+ and single O4+ cells sorted directly from postnatal day7 rat whole brain dissociates using flow cytometry.

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Project description:Expression data in KSHV-infected primary rat mesenchymal precursor (MM) cells

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Homo sapiens

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Project description:Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

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Transcriptome Profiling of Rattus norvegicus Embryonic Stem Cells by RNA-Sequencing

Project description:In order to establish a rat embryonic stem cell transcriptome, mRNA from rESC cell line DAc8, the first male germline competent rat ESC line to be described and the first to be used to generate a knockout rat model was characterized using RNA sequencing (RNA-seq) analysis.

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Radiation effects on gene expression in rat testes (Rattus norvegicus)

Project description:Analysis of LBNF1 rat testes from controls, containing both somatic and all germ cell types and from irradiated rats in which all cells germ cells except type A spermatgogonia are eliminated. Results provide insight into distinguishing germ and somatic cell genes and identification of somatic cell genes that are upregulated after irradiation.

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2016-07-22 | E-GEOD-74893 | biostudies-arrayexpress

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