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Leishmania major strain Friedlin

ABSTRACT: Transcriptionally Driven DNA Replication Programme of the Human Parasite Leishmania major

PROVIDER: PRJNA323581 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3593581_1.fastq.gz	Fastqsanger.gz
	SRR3593581_2.fastq.gz	Fastqsanger.gz
	SRR3593582_1.fastq.gz	Fastqsanger.gz
	SRR3593582_2.fastq.gz	Fastqsanger.gz
	SRR3593583_1.fastq.gz	Fastqsanger.gz

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Project description:Monocyte derived dendritic cells (MDDC) were infected with Leishmania major or Leishmania donovani parasites and collected at 4, 8, and 24 hours post-infection to analyze the differential effects those parasite species have on human host cell gene expression over time. Monocyte derived dendritic cells (MDDC) were generated from blood buffy coats collected from five anonymous healthy human donors and infected 10:1 (parasite to host cell) with Leishmania major Friedlin V1 strain or Leishmania donovani 1S strain parasites, where after 4, 8, or 24 hours total RNA was harvested from cells, cDNA generated, and hybridized to human gene transcipt expression arrays to assess differential host cell gene transcriptional expression differences relative to uninfected cells.

2015-01-02 | E-GEOD-64610 | biostudies-arrayexpress

Transcriptionally Driven DNA Replication Programme of the Human Parasite Leishmania major

Project description:Faithful inheritance of the large eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins. Although origin activation is mechanistically conserved among eukaryotes, how replication origins are specified and selected for activation in each S-phase seem to differ across the model systems studied. Here we provide a complete analysis of the nucleosomal landscape and replication programme of the human parasite Leishmania major, building on a better evolutionary understanding of replication organization in Eukarya. We found that active transcription is a driving force for the nucleosomal organization of L. major genome, and that both the spatial and the temporal programme of DNA replication can be explained as associated to RNA polymerase kinetics, without the need to invoke specific regulatory mechanisms. This simple scenario likely provides these organisms with the flexibility and robustness to deal with the continuous environmental changes that impose alterations in their genetic programmes during their parasitic life cycle stages. Our findings also suggest that coupling replication initiation to transcription elongation could be an ancient solution used by eukaryotic cells for origin maintenance

2016-06-10 | GSE81991 | GEO

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