Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers

PROVIDER: PRJNA326060 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3679315.fastq.gz	Fastqsanger.gz
	SRR3679316.fastq.gz	Fastqsanger.gz
	SRR3679317.fastq.gz	Fastqsanger.gz
	SRR3679318.fastq.gz	Fastqsanger.gz
	SRR3679319.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Drosophila melanogaster

Project description:Chromatin associated RNAi components take part in active transcriptional regulation in Drosophila

| PRJDB2780 | ENA

Drosophila melanogaster

Project description:Drosophila CNS glial microarray

| PRJNA198727 | ENA

Drosophila melanogaster

Project description:Drosophila CNS OXPHOS inhibition microarray

| PRJNA379770 | ENA

Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers

Project description:Transcriptional analysis of Drosophila CNS midline cells provides a useful system for studying transcriptional regulation at the genomic level due to a well-characterized set of midline-expressed genes and in vivo-validated enhancers. To investigate how access to regulatory information is controlled during midline cell development, we performed FAIRE-seq on FACS-purified midline cells. We find that regions of the genome with a strong midline FAIRE peak and weak whole-embryo FAIRE peak (“midline-enriched”) often correspond to midline enhancers near a midline-expressed gene and provides a useful predictive tool. Analysis of a large collection of midline enhancers revealed that those with a midline-enriched peak were located near midline-expressed genes, as were about half of the midline enhancers that overlapped a midline FAIRE peak that was not statistically "midline-enriched". There is a substantial fraction of midline enhancers that do not have a midline FAIRE peak and these tend to reside in chromatin regions that are not transcriptionally active and thus, unlikely to drive midline activity in vivo. This study emphasizes the utility of combining chromatin analysis of purified cell populations with gene expression and enhancer datasets to determine an experimentally useful chromatin profile that identifies biologically relevant enhancers and genes.

2016-10-18 | GSE83463 | GEO

Drosophila melanogaster

Project description:Drosophila MSL complex selectively identifies active genes on the male X chromosome

| PRJNA101721 | ENA

Drosophila melanogaster

Project description:Drosophila CNS mitochondrial DNA dysfunction microarray

| PRJNA232174 | ENA

Drosophila melanogaster

Project description:Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila

| PRJNA178575 | ENA

Drosophila melanogaster

Project description:Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context (mRNA)

| PRJNA156275 | ENA

Polyploidy in the adult Drosophila melanogaster brain

Project description:To understand gene expression changes in different regions of the Drosophila brain with age, we performed RNAseq different regions of the adult drosophila CNS at different ages.

2020-06-25 | GSE153165 | GEO

Drosophila melanogaster

Project description:Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context (ChIP-chip)

| PRJNA156273 | ENA