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Homo sapiens

ABSTRACT: The effect of ADAM12 knockdown on gene expression in SUM159PT breast cancer cells

PROVIDER: PRJNA327112 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3735310.fastq.gz	Fastqsanger.gz
	SRR3735311.fastq.gz	Fastqsanger.gz
	SRR3735312.fastq.gz	Fastqsanger.gz
	SRR3735313.fastq.gz	Fastqsanger.gz
	SRR3735314.fastq.gz	Fastqsanger.gz

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Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a

Project description:Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors. However, the role of lncRNA in breast cancer remains unclear. We performed microarrays to identify the differentially expressed mRNAs and lncRNAs in breast tissues with or without miR-34a knockout. In vitro and in vivo assays were preformed to explore the biological effects of the differentially expressed mRNA and lncRNA in breast cancer cells. We found that Adam12 and lnc015192 were significantly upregulated in miR-34a knockout breast tissues. Knockdown of Adam12 and lnc015192 inhibited breast cancer cells migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and in vivo. Further study indicated that lnc015192 acted as a competing endogenous RNA (ceRNA) for miR-34a to regulate Adam12 expression. Taken together, our findings demonstrate how Adam12 and lnc015192 induce breast cancer metastasis and offer novel therapeutic targets for breast cancer.

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