Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA328869 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR3883420.fastq.gz | Fastqsanger.gz | |||
| SRR3883421.fastq.gz | Fastqsanger.gz | |||
| SRR3883412.fastq.gz | Fastqsanger.gz | |||
| SRR3883422.fastq.gz | Fastqsanger.gz | |||
| SRR3883413.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 14 |
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This model is hosted on
BioModels Database
and identified by:
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To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.
2017-06-09 | MODEL1610060001 | BioModels
Project description:Hamey2017 - Blood stem cell regulatory
network
This model is described in the article:
Reconstructing blood stem
cell regulatory network models from single-cell molecular
profiles
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Sarah J. Kinston, David G. Kent, Nicola K. Wilson, and Berthold
Göttgens
Proceedings of the National Academy of
Sciences of the United States of America
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Adult blood contains a mixture of mature cell types, each
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This model is hosted on
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To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.
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Project description:Blood and cardiovascular development represent paradigms of embryonic organ formation, with increasingly specialised cells generated from early mesoderm. Here, we map the progression of mesoderm towards blood by single cell expression analysis of 3,934 cells, aiming to capture an entire embryo equivalent of cells with blood-forming potential at four sequential developmental stages. Using novel computational approaches, we reconstruct the developmental journey at single cell resolution, which reveals asynchrony of maturation and sequential waves of expression for major regulators. Considering transitions between individual cellular states, we synthesise executable transcriptional regulatory network models that recapitulate blood development. Using mouse embryos and embryonic stem cells, we validate model predictions by showing that Sox7 inhibits primitive erythropoiesis, and that Sox and Hox factors control early expression of Erg. We therefore demonstrate that single cell analysis of a developing organ coupled with novel computational approaches can reveal the transcriptional programs that control organogenesis. Transcriptome analysis in populations of 50 cells from each of 5 mouse embryos at primitive streak, neural plate and head fold stages of development
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