Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA329111 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR3922630_1.fastq.gz | Fastqsanger.gz | |||
| SRR3922630_2.fastq.gz | Fastqsanger.gz | |||
| SRR3922640_1.fastq.gz | Fastqsanger.gz | |||
| SRR3922640_2.fastq.gz | Fastqsanger.gz | |||
| SRR3922650.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 45 |
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Project description:Estrogen Receptor αlpha (ERα) is the master regulator of estrogen signaling in hormone-responsive breast cancer (BC), however epigenetic mechanisms, including DNA methylation, are emerging as key processes for regulation of critical cell functions including tumorigenesis. We have recently reported the epigenetic writer DOT1L (DOT1 Like Histone Lysine Methyltransferase) to associated to ERα, part of chromatin bound multiprotein complex and that the pharmacological inhibition of this enzyme reduces the transcription rate of several genes involved in ERα-mediated signaling leading to inhibition of BC cell proliferation. Here, we investigated the functional impact of DOT1L inhibition on methylome changes in BC and its possible contribution to deregulation of transcriptional pathways associated to the progression of this disease.
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