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Homo sapiens

ABSTRACT: Transcriptional regulation by H3F3A in A549 lung cancer cell

PROVIDER: PRJNA329449 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3928206_1.fastq.gz	Fastqsanger.gz
	SRR3928206_2.fastq.gz	Fastqsanger.gz
	SRR3928197_1.fastq.gz	Fastqsanger.gz
	SRR3928197_2.fastq.gz	Fastqsanger.gz
	SRR3928247_1.fastq.gz	Fastqsanger.gz

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Histone variant H3F3A promotes lung cancer cell migration through intronic regulation.

Project description:Although several somatic single nucleotide variations in histone H3.3 have been investigated as cancer drivers, other types of aberrations have not been well studied. Here, we demonstrate that overexpression of H3F3A, encoding H3.3, is associated with lung cancer progression and promotes lung cancer cell migration by activating metastasis-related genes. H3.3 globally activates gene expression through the occupation of intronic regions in lung cancer cells. Moreover, H3.3 binding regions show characteristics of regulatory DNA elements. We show that H3.3 is deposited at a specific intronic region of GPR87, where it modifies the chromatin status and directly activates GPR87 transcription. The expression levels of H3F3A and GPR87, either alone or in combination, are robust prognostic markers for early stage lung cancer, and may indicate potential for the development of treatments involving GPR87 antagonists. Our results demonstrate that intronic regulation by H3F3A may be a target for the development of novel therapeutic strategies. We performed microarray-based global gene expression analysis of H3F3A-overexpressing and H3F3A knockdown A549 cells.

2017-08-12 | GSE84555 | GEO

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Project description:homo lung cancer cell(A549) RNA-seq

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Project description:MicroRNA transcriptional regulation in lung cancer

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Project description:miRNA expression of lung cancer cells A549 and cisplatin (DDP) resistant lung cancer cells A549/DDP

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Project description:Resveratrol action on A549 lung cancer cells

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Homo sapiens

Project description:A549 Lung Epithelial Cell line Transcriptome

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CIT - Homo sapiens - APUP - Genomic aberrations in Lung Adenocarcinoma in Never Smokers

Project description:41 lung adenocarcinoma from never-smokers hybridized on Illumina SNP arrays on 13 HumanCNV370-Quadv3 chips. High-resolution array comparative genomic hybridization analysis of lung adenocarcinoma in 41 never smokers for identification of new minimal common regions (MCR) of gain or loss. The SNP array analysis validated copy-number aberrations and revealed that RB1 and WRN were altered by recurrent copy-neutral loss of heterozygosity.The present study has uncovered new aberrations containing cancer genes. The oncogene FUS is a candidate gene in the 16p region that is frequently gained in never smokers. Multiple genetic pathways defined by gains of MYC, deletions of RB1 and WRN or gains on 7p and 7q are involved in lung adenocarcinoma in never smokers. A 'Cartes d'Identite des Tumeurs' (CIT) project from the French National League Against Cancer (http://cit.ligue-cancer.net) 41 samples hybridized on Illumina SNP arrays. Submitter : Fabien PETEL petelf@ligue-cancer.net . Project leader : Pr Pierre FOURET pierre.fouret@psl.aphp.fr

2011-07-28 | E-TABM-1169 | biostudies-arrayexpress

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Project description:miRNA let-7a-3 overexpression in lung cancer cell line A549

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Homo sapiens MSCs: Normoxia vs. Hypoxia

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