Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Eopsaltria australis

ABSTRACT: Eopsaltria australis Raw sequence reads

PROVIDER: PRJNA329588 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3943050.fastq.gz	Fastqsanger.gz
	SRR3943060.fastq.gz	Fastqsanger.gz
	SRR3943070.fastq.gz	Fastqsanger.gz
	SRR3943080.fastq.gz	Fastqsanger.gz
	SRR3943090.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 81

Similar Datasets

Eopsaltria australis

Project description:Eopsaltria australis

| PRJNA958888 | ENA

Eopsaltria australis

Project description:Eopsaltria australis overview

| PRJNA182819 | ENA

Eopsaltria australis isolate:EYR054

Project description:Eopsaltria australis isolate:EYR054 Genome sequencing and assembly

| PRJNA476023 | ENA

Eopsaltria australis

Project description:The role of neo-sex chromosome architecture in promoting mitonuclear co-adaptation in Eopsaltria australis

| PRJNA1006346 | ENA

Eopsaltria griseogularis

Project description:Eopsaltria griseogularis

| PRJNA958889 | ENA

Phragmites australis

Project description:Phragmites australis Raw sequence reads

| PRJNA1032252 | ENA

Posidonia australis

Project description:Posidonia australis Raw sequence reads

| PRJNA814990 | ENA

Phragmites australis

Project description:Phragmites australis Raw sequence reads

| PRJNA1156343 | ENA

Phragmites australis cultivar:Phragmites australis root

Project description:Phragmites australis cultivar:Phragmites australis root Raw sequence reads

| PRJNA1140829 | ENA

Subversion of host innate immunity by Rickettsia australis via a modified autophagic response in macrophages

Project description:We recently reported that the in vitro and in vivo survival of Rickettsia australis are Atg5-dependent, in association with an inhibited level of anti-rickettsial cytokine, IL-1β. In the present study, we sought to investigate how R. australis interacts with host innate immunity via an Atg5-dependent autophagic response. We found that the serum levels of IFN-γ and G-CSF in R. australis-infected Atg5flox/floxLyz-Cre mice were significantly less compared to Atg5flox/flox mice, accompanied by significantly lower rickettsial loads in tissues with inflammatory cellular infiltrations including neutrophils. R. australis infection differentially regulated a significant number of genes in bone marrow-derived macrophages (BMMs) in an Atg5-depdent fashion as determined by RNA sequencing and Ingenuity Pathway Analysis, including genes in the molecular networks of IL-1 family cytokines and PI3K-Akt-mTOR. The secretion levels of inflammatory cytokines, such as IL-1α, IL-18, TNF-α, and IL-6, by R. australis-infected Atg5flox/floxLyz-Cre BMMs were significantly greater compared to infected Atg5flox/flox BMMs. Interestingly, R. australis significantly increased the levels of phosphorylated mTOR and P70S6K at a time when the autophagic response is induced. Rapamycin treatment nearly abolished the phosphorylated mTOR and P70S6K but did not promote significant autophagic flux during R. australis infection. These results highlight that R. australis modulates an Atg5-dependent autophagic response, which is not sensitive to regulation by mTORC1 signaling in macrophages. Overall, we demonstrate that R. australis counteracts host innate immunity including IL-1β-dependent inflammatory response to support the bacterial survival via an mTORC1-resistant autophagic response in macrophages.

2021-04-06 | GSE171160 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data