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Comprehensive expression profiling reveals the potential role of lncRNAs and circRNAs in systemic lupus erythematosus

ABSTRACT: Comprehensive expression profiling reveals the potential role of lncRNAs and circRNAs in systemic lupus erythematosus

PROVIDER: PRJNA330775 | ENA |

REPOSITORIES: ENA

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Comprehensive circRNAs expression profiling reveals the potential role of circRNAs in systemic lupus erythematosus [Human circRNA Array v2.0]

Project description:CircRNAs are novel non-coding RNAs which can serve as microRNA sponge and regulate gene transcription through promoting expression of their parent genes or competing with splicing of their parent genes. Moveover, there is increasing evidence showing that aberrant expressions of circRNAs are implicated in various cancers. Yet, their roles in systemic lupus erythematosus (SLE), a prototypical autoimmune disease, remain unknown. To reveal the implications of circRNAs in SLE, we used Human circRNA Array v2.0 microarrays to measure the expression profiles of circRNAs in T cells of patients with SLE and healthy controls. We found 129 differentially expressed circRNAs (fold change >2; P <0.05) in SLE patients compared with controls. Home-made computer program based on TargetScan and miRanda was applied to predict miRNA targets of circRNAs and identify 5 miRNAs with the highest mirSVR score for each circRNA.Downregulation of circRNA hsa_circ_0045272 was established using Real-time quantitative PCR. These results showed abrrant expression profiles of circRNAs in T cells of SLE patients and revealed their potential role in SLE.

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Comprehensive lncRNAs expression profiling reveals the potential role of lncRNAs in systemic lupus erythematosus [Human LncRNA Array v3.0]

Project description:long non-coding RNAs (lncRNAs) are novel non-coding RNAs which play an important part in regulating gene transcription and translation, modulating protein function, and acting as competing endogeneous RNA. Moveover, there is increasing evidence showing that aberrant expressions of lncRNAs are implicated in various cancers. Yet, their roles in systemic lupus erythematosus (SLE), a prototypical autoimmune disease, remain unknown. To reveal the implications of LncRNAs in SLE, we used Human LncRNA Array v3.0 microarrays to measure the expression profiles of lncRNAs in T cells of patients with SLE and healthy controls. we found 869 upregulated lncRNAs and 1066 downregulated lncRNAs in SLE patients compared with controls. Coding-non-coding gene coexpression (CNC) network was constructed based on the correlation analysis between the differentially expressed lncRNA and mRNA. Downregulation of two lncRNAs, uc001ykl.1 and ENST00000448942 was established using Real-time quantitative PCR. These results showed abrrant expression profiles of lncRNAs in T cells of SLE patients and revealed their potential role in SLE.

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