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Homo sapiens

ABSTRACT: CRISPR screen for survival factors of primary effusion lymphoma cell lines

PROVIDER: PRJNA336172 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4014700.fastq.gz	Fastqsanger.gz
	SRR4014710.fastq.gz	Fastqsanger.gz
	SRR4014701.fastq.gz	Fastqsanger.gz
	SRR4014711.fastq.gz	Fastqsanger.gz
	SRR4014702.fastq.gz	Fastqsanger.gz

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microRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP

Project description:This SuperSeries is composed of the following subset Series: GSE31745: Primary effusion lymphoma cell lines BC-1 and BC-3 GSE31746: BJAB Cell Lines Transduced with lentiviral vector pNL-SIN-CMV-AcGFP expressing KSHV miRNAs miR-K1, miR-K12-11, or miR-K4-3p GSE32109: microRNA Targetome Analysis of Latently KSHV-infected Primary Effusion Lymphoma Cell lines Using PAR-CLIP [Illumina] Refer to individual Series

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Project description:Microarray analysis of primary effusion lymphoma cell lines BC-1 and BC-3

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Project description:Non-Hodgkin lymphomas (NHL) make up the majority of lymphoma diagnoses and represent a very diverse set of malignancies. We sought to identify kinases uniquely upregulated in different NHL subtypes. Using Multiplexed Inhibitor Bead-mass spectrometry (MIB/MS), we found Tyro3 was uniquely upregulated and important for cell survival in primary effusion lymphoma (PEL), which is a viral lymphoma infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).

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CRISPR screens for synthetic rescue of cFLIP depletion in primary effusion lymphoma cell lines

Project description:CRISPR screens for synthetic rescue of cFLIP depletion in primary effusion lymphoma cell lines

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mRNA-Seq of BC-3 IRF4 KO, BATF KO, and vIRF3 KD

Project description:The Kaposi's sarcoma-associated herpesviruses causes several cancers including Kaposi's sarcoma and primary effusion lymphoma (PEL). Our work reveals that the cellular transcription factors interferon regulatory factor 4 (IRF4) and basic leucine zipper ATF-like transcription factor (BATF), as well as the viral interferon regulatory factor 3 (vIRF3) are critical oncogenic dependencies specific to PEL cell lines. To understand the functions of these transcription factors, we performed mRNA-Seq on the PEL BC-3 cell lines that have been targeted for CRISPR/Cas9 IRF4 KO, BATF KO and MDM4 KO (as unrelated negative control) and CRISPRi-mediated vIRF3 KD. Our results reveal that these oncogenic factors may cooperate to regulate the expression of the same mRNAs.

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2011-06-23 | GSE28684 | GEO

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