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Moraxella catarrhalis

ABSTRACT: Moraxella catarrhalis Raw sequence reads

PROVIDER: PRJNA338378 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR4240461_1.fastq.gz	Fastqsanger.gz
	SRR4240461_2.fastq.gz	Fastqsanger.gz
	SRR4240473_1.fastq.gz	Fastqsanger.gz
	SRR4240473_2.fastq.gz	Fastqsanger.gz
	SRR4240474_1.fastq.gz	Fastqsanger.gz

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Project description:During the course of infection, respiratory pathogens like Moraxella catarrhalis needs to adhere to epithelial cells of different host niches such as the nasopharynx and lungs. Consequently, efficient adhesion to epithelial cells is considered an important virulence trait of M. catarrhalis. We examined the interaction between human pharyngeal epithelial Detroit 562 cells and M. catarrhalis BBH18 during adherence using a combination of Tn-seq, a genome-wide negative selection screenings technology, and expression profiling of both host and pathogen. The results described in this study are further discussed in Stefan P.W. de Vries, Marc J. Eleveld, Peter W.M. Hermans, Hester J. Bootsma: Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells, submitted.

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Cytosolic immunity against Moraxella catarrhalis requires innate immune signalling pillars converging on inflammasome activation

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