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Rattus norvegicus

ABSTRACT: DLX3 binding sites in rat enamel organ

PROVIDER: PRJNA338481 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4018121.fastq.gz	Fastqsanger.gz
	SRR4018122.fastq.gz	Fastqsanger.gz
	SRR4018123.fastq.gz	Fastqsanger.gz

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DLX3 binding sites in rat enamel organ

Project description:DLX3 is a homeodomain transcription factor involved in amelogenesis. Mutations in DLX3 in human lead to Tricho-Dento-Osseous syndrome featuring enamel hypoplasia and hypomineralization. Here we investigated the distribution of DLX3 DNA binding sites in rat enamel organ using ChIP-seq.

2020-02-11 | GSE85451 | GEO

Molecular consequences of Dlx3 deletion in mouse enamel organ as determined by RNASeq analysis

Project description:DLX3 is a homeodomain transcription factor involved in ameloblast differentiation and enamel formation. Mutations in DLX3 in human lead to defects in enamel. However, the downstream targets of Dlx3 transcriptional activity in the enamel organ have not been identified yet. In this study, we compared the transcriptome of enamel organs where Dlx3 has been deleted to control tissues. Total RNA was extracted from enamel organs (mandibular incisors) from Dlx3-WT (N=4) and Dlx3-K14cKO (N=4) mice at P10. cDNA libraries were generated using NEBnext and NuGen kits. Sequencing was performed on the HiSeq2000.

2015-05-14 | E-GEOD-57984 | biostudies-arrayexpress

Molecular consequences of Dlx3 deletion in mouse enamel organ as determined by RNASeq analysis

2015-05-14 | GSE57984 | GEO

Molecular consequences of Dlx3 deletion in mouse enamel organ as determined by microarray analysis

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