Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fireflies and Rhagophthalmids

ABSTRACT: Transcriptomic and mitochondrial data uncover the phylogenetic position of Rhagophthalmids

PROVIDER: PRJNA339505 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR4045940_1.fastq.gz	Fastqsanger.gz
	SRR4045940_2.fastq.gz	Fastqsanger.gz
	SRR4045941_1.fastq.gz	Fastqsanger.gz
	SRR4045941_2.fastq.gz	Fastqsanger.gz
	SRR4045938_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Project description:Phylogenetic position of Nesodexia

| PRJNA863378 | ENA

Tsukubamonas globosa

Project description:The phylogenetic position of Tsukubamonas globosa

| PRJDB2356 | ENA

Mylodon

Project description:The phylogenetic position of Mylodon darwinii

| PRJEB20732 | ENA

Project description:Phylogenetic position of Clinterocera nigra (Scarabaeidae, Coleoptera)

| PRJNA806699 | ENA

THE PHYLOGENETIC POSITION OF THE GENUS CLAOPODIUM

Project description:THE PHYLOGENETIC POSITION OF THE GENUS CLAOPODIUM

| PRJEB39346 | ENA

coral metagenome

Project description:Phylogenetic position of the coral symbiont Ostreobium inferred from chloroplast genome data

| PRJNA362979 | ENA

Phrix spatulata

Project description:Phylogenetic position of a red alga from Easter Island

| PRJEB23423 | ENA

RNA-seq transcriptional profiling in human primary fetal and adult CD34+ hematopoietic stem/progenitor cells (HSPCs) erythroid progenitor cells (ProEs)

Project description:Advances in sequencing-based genomic profiling present a new challenge of explaining how changes in DNA/RNA are translated into proteins linking genotypes to phenotypes. The developing erythroid cells require highly coordinated gene expression and metabolism, and serve as a unique model in dissecting regulatory events in development and disease. Here we compare the proteomic and transcriptomic changes in human hematopoietic stem/progenitor cells and lineage-committed erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Two principal mitochondrial factors TFAM and PHB2 are tightly regulated at the protein level and indispensable for mitochondria and erythropoiesis. mTORC1 signaling is progressively enhanced to promote translation of mitochondrial proteins during erythroid specification. Genetic and pharmacological perturbation of mTORC1 or mitochondria impairs erythropoiesis. Our studies suggest a new mechanism for regulation of mitochondrial biogenesis through mTORC1-mediated protein translation, and may have direct relevance to the hematological defects associated with mitochondrial diseases and aging. Transcriptional profiling in human primary fetal and adult CD34+ hematopoietic stem/progenitor cells (HSPCs) erythroid progenitor cells (ProEs) by RNA-seq analysis.

2017-05-15 | E-GEOD-74053 | biostudies-arrayexpress

ChIP-seq analysis of H3K27ac in K562 cells with shRNA-mediated depeltion of TFAM expression

Project description:The developing erythroid cells require highly coordinated gene expression and metabolism. By comparing the proteomic and transcriptomic changes in human hematopoietic stem/progenitor cells (HSPCs) and lineage-committed erythroid progenitors (ProEs), and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Two principal mitochondrial factors TFAM and PHB2 are tightly regulated at the protein level and indispensable for mitochondria and erythropoiesis. Depletion of TFAM in erythroid cells alters intracellular metabolism, leading to elevated histone acetylation, deregulated gene expression, defective mitochondria function and erythropoiesis.

2017-05-15 | GSE86864 | GEO

Project description:Phylogenomic studies to elucidate the phylogenetic position of interstitial annelids. transcriptome

| PRJNA282709 | ENA