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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

ABSTRACT: The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

PROVIDER: PRJNA340144 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4064670_1.fastq.gz	Fastqsanger.gz
	SRR4064670_2.fastq.gz	Fastqsanger.gz
	SRR4064680_1.fastq.gz	Fastqsanger.gz
	SRR4064680_2.fastq.gz	Fastqsanger.gz
	SRR4064690_1.fastq.gz	Fastqsanger.gz

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Macaque_450k]

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Macaque_450k]

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

Project description:We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. The replicated aDMPs show a faster rate of change with age in the shorter lived dog species. Strikingly, these aDMPs also show a faster rate of change with age in dogs overall compared with humans.

2018-01-17 | GSE86058 | GEO

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Macaque_450k]

Project description:We used blood samples from Macaque to determine rate of change of methylation with respect to age.

2018-01-17 | GSE104217 | GEO

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [TC1_450k]

Project description:We used liver samples from TC1 Mice to determine rate of change of methylation with respect to age.

2018-01-17 | GSE104216 | GEO

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: naked mole-rat]

Project description:We used liver samples from Naked Mole Rat to determine rate of change of methylation with respect to age.

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-01-17 | GSE86059 | GEO

Canis lupus familiaris

Project description:The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

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Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells [aal1OE_RNAseq]

Project description:Genomes pervasively produce long non-coding RNAs (lncRNAs) of largely unknown functions. Some of these lncRNAs have been implicated in roles related to ageing and associated diseases. Here we characterize aal1 (ageing-associated lncRNA 1) which is induced in non-dividing, ageing cells of fission yeast. Deletion of aal1 shortens the chronological lifespan of non-dividing cells, while ectopic overexpression of aal1 from a plasmid prolongs their lifespan, indicating that this lncRNA acts in trans. We find that aal1 genetically interacts with coding genes functioning in processes related to protein translation, and aal1 overexpression leads to repression of ribosomal protein genes and inhibition of cell growth. The aal1 RNA localizes to the cytoplasm and associates with ribosomes. Notably, aal1 deletion or overexpression is sufficient to increase or decrease the cellular ribosome content, respectively. We identify the mRNA rpl1901, encoding a ribosomal protein, as a binding target of aal1. The expression of rpl1901 is moderately repressed by aal1, and such moderate repression is critical and sufficient to extend the chronological lifespan. Remarkably, expression of the yeast aal1 lncRNA in the fly gut triggers a significant extension of the lifespan in flies. Based on these findings, we propose that the aal1 RNA can reduce the ribosome content by decreasing the levels of the Rpl1901 ribosomal protein, thus attenuating protein translation and promoting longevity. Although the aal1 lncRNA itself is not conserved, its effects in the fly raise the possibility that other organisms feature related mechanisms involving conserved ribosome-associated processes to control ageing.

2024-10-21 | GSE243034 | GEO

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