Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA344315 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR4293033.fastq.gz | Fastqsanger.gz | |||
| SRR4293034.fastq.gz | Fastqsanger.gz | |||
| SRR4293035.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 3 of 3 |
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Project description:Identification of PU. 1 target genes in mouse developing pro-B cells
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Project description:We examined the genomic PU.1 binding profile in mouse developing pro-B cells by using chromatin immunoprecipitation following high-throughput sequencing (ChIP-seq). Our goal was to determine the genes regulated by PU.1 specifically at the pro-B cell stage in B cell development.
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Project description:Genome wide WT1 binding sites in developing mouse kidneys
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Project description:Introgressed variants from other species can be an important source of genetic variation because they may arise rapidly, can include multiple mutations on a single haplotype, and have often been pretested by selection in the species of origin. Although introgressed alleles are generally deleterious, several studies have reported introgression as the source of adaptive alleles-including the rodenticide-resistant variant of Vkorc1 that introgressed from Mus spretus into European populations of Mus musculus domesticus. Here, we conducted bidirectional genome scans to characterize introgressed regions into one wild population of M. spretus from Spain and three wild populations of M. m. domesticus from France, Germany, and Iran. Despite the fact that these species show considerable intrinsic postzygotic reproductive isolation, introgression was observed in all individuals, including in the M. musculus reference genome (GRCm38). Mus spretus individuals had a greater proportion of introgression compared with M. m. domesticus, and within M. m. domesticus, the proportion of introgression decreased with geographic distance from the area of sympatry. Introgression was observed on all autosomes for both species, but not on the X-chromosome in M. m. domesticus, consistent with known X-linked hybrid sterility and inviability genes that have been mapped to the M. spretus X-chromosome. Tract lengths were generally short with a few outliers of up to 2.7 Mb. Interestingly, the longest introgressed tracts were in olfactory receptor regions, and introgressed tracts were significantly enriched for olfactory receptor genes in both species, suggesting that introgression may be a source of functional novelty even between species with high barriers to gene flow.
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Project description:ETS trancription factors PU.1 and Spi-B binding in mouse lymphoma cells
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Project description:Selvarasu2009 - Genome-scale metabolic
network of Mus Musculus (iSS724)
This model is described in the article:
Genome-scale modeling and in
silico analysis of mouse cell metabolic network.
Selvarasu S, Karimi IA, Ghim GH, Lee
DY.
Mol Biosyst 2010 Jan; 6(1):
152-161
Abstract:
Genome-scale metabolic modeling has been successfully
applied to a multitude of microbial systems, thus improving our
understanding of their cellular metabolisms. Nevertheless, only
a handful of works have been done for describing mammalian
cells, particularly mouse, which is one of the important model
organisms, providing various opportunities for both biomedical
research and biotechnological applications. Presented herein is
a genome-scale mouse metabolic model that was systematically
reconstructed by improving and expanding the previous generic
model based on integrated biochemical and genomic data of Mus
musculus. The key features of the updated model include
additional information on gene-protein-reaction association,
and improved network connectivity through lipid, amino acid,
carbohydrate and nucleotide biosynthetic pathways. After
examining the model predictability both quantitatively and
qualitatively using constraints-based flux analysis, the
structural and functional characteristics of the mouse
metabolism were investigated by evaluating network
statistics/centrality, gene/metabolite essentiality and their
correlation. The results revealed that overall mouse metabolic
network is topologically dominated by highly connected and
bridging metabolites, and functionally by lipid metabolism that
most of essential genes and metabolites are from. The current
in silico mouse model can be exploited for understanding and
characterizing the cellular physiology, identifying potential
cell engineering targets for the enhanced production of
recombinant proteins and developing diseased state models for
drug targeting.
This model is hosted on
BioModels Database
and identified by:
MODEL1507180042.
To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.
2015-07-30 | MODEL1507180042 | BioModels
Project description:Genome wide mapping of Dmrt3 and Dmrta2 binding sites in the developing mouse telencephalon.
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Project description:Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we evaluate the suitability of the white-footed deer mouse (Peromyscus leucopus) as a model organism for aging research, offering a comparative analysis against C57B6/J and diversity outbred (DO) Mus musculus strains. Our study includes comparisons of body composition, skeletal muscle function, and cardiovascular parameters, shedding light on potential applications and limitations of P. leucopus in aging studies. Notably, P. leucopus exhibits distinct body composition characteristics, emphasizing reduced muscle force exertion and a unique metabolism, particularly in fat mass. Cardiovascular assessments showed changes in arterial stiffness, challenging conventional assumptions and highlighting the need for a nuanced interpretation of aging-related phenotypes. Our study also highlights inherent challenges associated with maintaining and phenotyping P. leucopus cohorts. Behavioral considerations, including anxiety-induced responses during handling and phenotyping assessment, pose obstacles in acquiring meaningful data. Moreover, the unique anatomy of P. leucopus necessitates careful adaptation of protocols designed for Mus musculus. While showcasing potential benefits, further extensive analyses across broader age ranges and larger cohorts are necessary to establish the reliability of P. leucopus as a robust and translatable model for aging studies.
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