Project description:RNA-seq based indentification of responsive and critical genes which might be involved in the arsenopyrite (FeAsS) weathering by Lysinibacillus sp. B2A1
Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of 1918 genes connected with lipid metabolism in yeast strain overexpressed of fatty acid biosynthesis gene In the study presented here, expression profiles of wild type and ACC-overexpressed wild type yeast strain were well-clustered by profiles- and gene similarities. It was analyzed the gene expression profile of ACC-overexpressing as compared with those of wild type. The expression levels between wild type(WT) and ACC-overexpressed wild type(ACC) were compared individually three times.
Project description:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy accounting for between 0.02 and 0.2 percent of all cancer deaths. Surgical removal offers the only current potential for cure. Unfortunately, ACC has undergone metastatic spread in approximately 40-70 percent of patients at the time of diagnosis. Standard chemotherapy with mitotane containing regimens is often ineffective and associated with intolerable side-effects. Modern molecular technologies now allow the examination of germ-line and somatic DNA for chromosomal alterations which can give biological insight into cancer processes. Using an array-based high density comparative genomic hybridization (CGH) screen, genomic aberrations within 25 ACC patients were assessed to identify genomic characteristic of this cancer. Genomes were queried with >44,000 probes on the Agilent Human Genome CGH array detecting regions of chromosomal gain and loss within the tumor population. Statistical analysis of this genetic landscape reveals a set of chromosomal aberrations strongly associated with survival in an accumulation dependent fashion. These regions may hold prognostic indicators and offer therapeutic targets that can be used to develop novel treatments for aggressive tumors. Keywords: CGH, adrenocortical carcinoma, cancer