Project description:To explore the changes of local microenvironment in the feto-maternal interface during early pregnancy in RSA, we next examined the transcriptional profiles of the decidua tissue by RNA sequencing using samples from 3 RSA patients and 3 healthy controls

2021-06-22 | GSE178535 | GEO

Rhizobium esperanzae strain:SEMIA 468 | isolate:SEMIA 468

Project description:Rhizobium esperanzae SEMIA 468 genome sequencing

| PRJNA581070 | ENA

Dimargaris xerosporica strain:NRRL 3178 | isolate:NRRL 3178

Project description:Dimargaris xerosporica NRRL 3178 Resequencing genome sequencing

| PRJNA650748 | ENA

Populus trichocarpa strain:Besc-468

Project description:Populus trichocarpa strain:Besc-468 Genome sequencing

| PRJNA249379 | ENA

Pseudoalteromonas sp. YIC-468

Project description:Pseudoalteromonas sp. YIC-468 Genome sequencing

| PRJNA1093251 | ENA

Single-cell RNA-seq to decipher the subpopulations of human decidual leukocytes in normal and RSA pregnancies

Project description:Maternal fetal immune tolerance is a biological event that plays a key role in pregnancy. In particular, the mechanism by which the maternal immune system does not exclude the semi-identical antigen of the fetus has not been fully answered so far. The most serious result of the maternal fetal immune tolerance balance is the recurrent spontaneous abortion (RSA). The fetus is rejected by the mother in the early pregnancy and cannot continue to develop in the uterus. Based on these scientific questions, we used single-cell sequencing technology to analyze nearly 30,000 leukocytes in the decidua of normal and RSA. A total of 13 immune cell subsets were found, of which dNK cells were more prominent, The lineage differentiation pathway of dNK cells was excavated, and the pathological role of dNK differentiation abnormality in the occurrence of RSA was analyzed. Our results deepen our understanding of the differentiation and function of human decidual leukocytes, especially dNK cells. We clearly recognize that the immune system has dynamic changes compared with normal pregnancy under pathological conditions, which is likely to occur in RSA. The important factors, we expect our results to provide a new basis for RSA's immune diagnosis and treatment strategy.

2021-07-20 | GSE130560 | GEO

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