Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: miRNA expression profiling of alcohol exposure in Drosophila melanogaster

PROVIDER: PRJNA350386 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR4449242.fastq.gz	Fastqsanger.gz
	SRR4449243.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Drosophila melanogaster

Project description:Gene expression profiling of Drosophila melanogaster 30 minutes after alcohol exposure

| PRJNA311563 | ENA

Drosophila melanogaster

Project description:Transcriptional Response to Alcohol Exposure in Drosophila melanogaster

| PRJNA96289 | ENA

Drosophila melanogaster

Project description:Expression profiling of Drosophila melanogaster

| PRJNA79385 | ENA

Gene expression profiling of Drosophila melanogaster larval brains after chronich alcohol exposure

Project description:Gene expression profiling of Drosophila melanogaster larval brains after chronich alcohol exposure

| PRJNA770108 | ENA

Transcriptional Response to Alcohol Exposure in Drosophila melanogaster

Project description:The National Institute on Alcohol Abuse and Alcoholism has estimated that approximately 14 million people in the United States suffer from alcoholism. Alcohol sensitivity, the development of tolerance to alcohol and susceptibility to addiction vary in the population. Whereas environmental factors, such as stress and social experience, contribute to individual variation in sensitivity to chronic alcohol consumption, genetic factors have also been implicated. However, genetic polymorphisms that predispose to alcoholism remain largely unknown due to extensive genetic and environmental variation in human populations. Drosophila, however, allows studies on genetically identical individuals in controlled environments. Although addiction to alcohol has not been demonstrated in Drosophila, flies show responses to alcohol exposure that resemble human intoxication, including hyperactivity, loss of postural control, sedation, and exposure-dependent development of tolerance. We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of olfactory sensitivity and, concomitant with development of tolerance, altered transcription of enzymes associated with fatty acid biosynthesis. Our results identify key enzymes in conserved metabolic pathways that may contribute to human alcohol sensitivity. Keywords: Drosophila, model system, alcohol sensitivity, tolerance

2006-07-27 | GSE5382 | GEO

Drosophila melanogaster

Project description:Expression profiling of Hyperoxia-Tolerant Drosophila melanogaster

| PRJNA113447 | ENA

Total RNA-seq from Drosophila melanogaster.

Project description:High-throughput sequencing was used to study mRNA and miRNA distribution in Drosophila melanogaster.

2021-09-01 | GSE163852 | GEO

Drosophila melanogaster

Project description:Acute ethanol exposure time-course in Drosophila melanogaster

| PRJNA119573 | ENA

Drosophila melanogaster

Project description:Differential gene expression following exposure to rivals in male Drosophila melanogaster.

| PRJNA241116 | ENA

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Project description:Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance. We performed artificial selection for alcohol sensitivity for 25 generations and created duplicate selection lines that are either highly sensitive or resistant to ethanol exposure along with unselected control lines. We used whole genome expression analysis to identify 1,678 probe sets with different expression levels between the divergent lines, pooled across replicates, at a false discovery rate of q < 0.001. We assessed to what extent genes with altered transcriptional regulation might be causally associated with ethanol sensitivity by measuring alcohol sensitivity of 37 co-isogenic P-element insertional mutations in 35 candidate genes, and found that 32 of these mutants differed in sensitivity to ethanol exposure from their co-isogenic controls. Furthermore, 23 of these novel genes have human orthologues. Combining whole genome expression profiling with selection for genetically divergent lines is an effective approach for identifying candidate genes that affect complex traits, such as alcohol sensitivity. Because of evolutionary conservation of function, it is likely that human orthologues of genes affecting alcohol sensitivity in Drosophila may contribute to alcohol-associated phenotypes in humans. Keywords: artificial selection, whole genome expression profiling

2007-11-20 | GSE7614 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data